Evidence map›Paper›PMID 33729722›Full record

ArticleCritical care medicine2021

Venoarterial Extracorporeal Membrane Oxygenation for Postcardiotomy Shock-Analysis of the Extracorporeal Life Support Organization Registry.

Mariusz Kowalewski, Kamil Zieliński, Daniel Brodie, Graeme MacLaren, Glenn Whitman, Giuseppe M Raffa, Udo Boeken, Kiran Shekar, Yih-Sharng Chen, Christian Bermudez and 12 more

Open access · greenAbstract read
In one paragraph

Article in Critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Circulatory Support for High-Risk Coronary Artery Bypass Grafting and Coronary Interventions: Where is the Evidence?The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 5 countries.

Mariusz KowalewskiDepartment of Cardio-Thoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.
Kamil ZielińskiWarsaw Medical University, Warsaw, Poland.
Daniel BrodieCenter for Acute Respiratory Failure and Department of Medicine, Columbia University College of Physicians & Surgeons/New York-Presbyterian Hospital, New York, NY.
Graeme MacLarenCardiothoracic Intensive Care Unit, National University Hospital, Singapore.
Glenn WhitmanCardiovascular Surgery Intensive Care Unit, Johns Hopkins Hospital, Baltimore, MD.
Giuseppe M RaffaCardiac Surgery Unit, ISMETT, Palermo, Italy.
Udo BoekenDepartment of Cardiac Surgery, University of Dusseldorf, Dusseldorf, Germany.
Kiran ShekarAdult Intensive Care Services, The Prince Charles Hospital, Brisbane, VIC, Australia.
Yih-Sharng ChenCardiovascular Surgery and Pediatric Cardiovascular Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Christian BermudezDepartment of Cardiothoracic Surgery, Jefferson University, Philadelphia, PA.
David D'AlessandroDepartment of Cardio-Thoracic Surgery, Massachusetts Medical Centre, Boston, MA.
Xiaotong HouCenter for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
Jonathan HaftSection of Cardiac Surgery, University of Michigan, Ann Arbor, MI.
Jan Belohlavek2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University, Prague, and General University Hospital, Prague, Czech Republic.
Inga DziembowskaDepartment of Pathophysiology, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Toruń, Poland.
Piotr SuwalskiClinical Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, Centre of Postgraduate Medical Education, Warsaw, Poland.
Peta AlexanderDepartment of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA.
Ryan P BarbaroDepartment of Pediatrics, C.S. Mott Children's Hospital, University of Michigan Ann Arbor, MI.
Mario GaudinoDepartment of Cardio-Thoracic Surgery, Well Cornell Medicine, New York, NY.
Michele Di MauroCardiac Surgery Unit, University Hospital, University of Chieti, Chieti, Italy.
Jos MaessenDepartment of Cardio-Thoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.
Roberto LorussoDepartment of Cardio-Thoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.
Maastricht University Medical Centre · NLBeijing Anzhen Hospital · CNCentral Clinical Hospital · PLHarvard University · USMaastricht University · NLMedical University of Warsaw · PLNational University Hospital · SGNicolaus Copernicus University · PLUniversity of Michigan–Ann Arbor · US

Funding

Training to Advance Care Through Implementation Science in Cardiac And Lung Illnesses (TACTICAL)K12HL138039 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARNES, GEOFFREY DOUGLAS, PRESCOTT, HALLIE CHRISTINE · 2017 to 2021
$3.1M
NHLBI NIH HHS K12 HL138039
6 · The paper itself

Abstract

objectivesRefractory postcardiotomy cardiogenic shock complicating cardiac surgery yields nearly 100% mortality when untreated. Use of venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock has increased worldwide recently. The aim of the current analysis was to outline the trends in use, changing patient profiles, and in-hospital outcomes including complications in patients undergoing venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock.

designAnalysis of extracorporeal life support organization registry from January 2010 to December 2018.

settingMulticenter worldwide registry. PATIENTS: Seven-thousand one-hundred eighty-five patients supported with venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock.

interventionsVenoarterial extracorporeal membrane oxygenation. MEASUREMENTS AND MAIN

resultsHospital death, weaning from extracorporeal membrane oxygenation, hospital complications. Mortality predictors were assessed by multivariable logistic regression. Propensity score matching was performed for comparison of peripheral and central cannulation for extracorporeal membrane oxygenation. A significant trend toward more extracorporeal membrane oxygenation use in recent years (coefficient, 0.009; p < 0.001) was found. Mean age was 56.3 ± 14.9 years and significantly increased over time (coefficient, 0.513; p < 0.001). Most commonly, venoarterial extracorporeal membrane oxygenation was instituted after coronary artery bypass surgery (26.8%) and valvular surgery (25.6%), followed by heart transplantation (20.7%). Overall, successful extracorporeal membrane oxygenation weaning was possible in 4,520 cases (56.4%), and survival to hospital discharge was achieved in 41.7% of cases. In-hospital mortality rates remained constant over time (coefficient, -8.775; p = 0.682), whereas complication rates were significantly reduced (coefficient, -0.009; p = 0.003). Higher mortality was observed after coronary artery bypass surgery (65.4%), combined coronary artery bypass surgery with valve (68.4%), and aortic (69.6%) procedures than other indications. Lower mortality rates were observed in heart transplantation recipients (46.0%). Age (p < 0.001), central cannulation (p < 0.001), and occurrence of complications while on extracorporeal membrane oxygenation were independently associated with poorer prognosis.

conclusionsThe analysis confirmed increased use of venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock. Mortality rates remained relatively constant over time despite a decrease in complications, in the setting of supporting older patients.

Indexed as

Cardiac Surgical ProceduresAdolescentAdultAgedAged, 80 and overAge FactorsCatheterization, Central VenousCatheterization, PeripheralCoronary Artery BypassExtracorporeal Membrane OxygenationFemaleHeart TransplantationHeart Valve Prosthesis ImplantationHospital MortalityHumansMale

Identifiers

PMID33729722
PMCPMC8217275
OpenAlexW3135701512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.