Evidence map›Paper›PMID 33729613›Full record

ReviewJournal of neuroscience research2021

Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers.

Karthik Krishnamurthy, Piera Pasinelli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Emerging perspectives of synaptic biomarkers in ALS and FTD.Frontiers in molecular neuroscience · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karthik KrishnamurthyDepartment of Neuroscience, Jefferson Weinberg ALS Center, Vickie & Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-2552-8912
Piera PasinelliDepartment of Neuroscience, Jefferson Weinberg ALS Center, Vickie & Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA.

Funding

Contribution of astrocytes to mutant FUS-linked Amyotrophic Lateral SclerosisR01NS109150 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2019 to 2023
$1.7M
Studies of NMJ structure and function in mutant FUS-ALS and beyondR56NS092572 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2015 to 2015
$478k
NINDS NIH HHS R01 NS109150NINDS NIH HHS R56 NS092572
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisAnimalsBiomarkersFrontotemporal DementiaHumansBiomarkersbiomarkerfrontotemporal dementiaFUSliquid-liquid phase separationmotor neuron disease/amyotrophic lateral sclerosisprotein aggregationstress granulessynaptic dysfunctionsynaptotagminTDP-43

Identifiers

PMID33729613
PMCPMC8085061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.