Evidence map›Paper›PMID 33729590›Full record

ArticleThe EMBO journal2021

N

Jimmy Lee, Yuchen Wu, Bryan T Harada, Yuanyuan Li, Jing Zhao, Chuan He, Yanlei Ma, Xiaoyang Wu

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Review
  6. Article
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  8. Review
  9. Article
  10. Article
  11. NZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  12. Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jimmy LeeBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-5547-4858
Yuchen WuBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Bryan T HaradaDepartment of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9683-782X
Yuanyuan LiBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Jing ZhaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Chuan HeDepartment of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4319-7424
Yanlei MaDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0000-0002-0632-5258
Xiaoyang WuBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6378-3207
University of Chicago · USHoward Hughes Medical Institute · USShanghai Medical College of Fudan University · CN

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Development of epidermal progenitor cell-based therapy for regenerative medicineR01OD023700 · OD · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG · 2017 to 2021
$2.4M
A cutaneous gene therapy for cocaine abuse and alcohol co-abuseR01DA047785 · NIDA · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG, XU, MING · 2019 to 2023
$2.2M
Coordinated cytoskeletal dynamics in skin somatic stem cells - Resubmission 01R01AR063630 · NIAMS · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG · 2013 to 2017
$1.7M
A Novel cutaneous gene therapy for combating alcohol use disorderR21AA027172 · NIAAA · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG, XU, MING · 2018 to 2019
$425k
Howard Hughes Medical InstituteNCI NIH HHS T32 CA009594NHGRI NIH HHS RM1 HG008935NIAAA NIH HHS R21 AA027172NIAMS NIH HHS R01 AR063630NIDA NIH HHS R01 DA047785NIH HHS R01 OD023700
6 · The paper itself

Abstract

Dynamic chemical modifications of RNA represent novel and fundamental mechanisms that regulate stemness and tissue homeostasis. Rejuvenation and wound repair of mammalian skin are sustained by epidermal progenitor cells, which are localized within the basal layer of the skin epidermis. N

Indexed as

Cell DifferentiationRNA Processing, Post-TranscriptionalAdenosineAnimalsCells, CulturedEpidermal CellsGuinea PigsMethyltransferasesMiceProtein BindingProto-Oncogene Proteins c-mycRNA, Long NoncodingStem CellsWound HealingAdenosineMethyltransferasesMettl14 protein, mouseN-methyladenosineProto-Oncogene Proteins c-mycPVT1 long-non-coding RNA, mouseRNA, Long Noncodingepidermal progenitor celllncRNAm6A modificationPvt1 signaling

Identifiers

PMID33729590
PMCPMC8047438
OpenAlexW3136409253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.