Evidence map›Paper›PMID 33729514›Full record

ArticleInternational journal of epidemiology2021

Reflection on modern methods: Dynamic prediction using joint models of longitudinal and time-to-event data.

Eleni-Rosalina Andrinopoulou, Michael O Harhay, Sarah J Ratcliffe, Dimitris Rizopoulos

Abstract read
In one paragraph

Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eleni-Rosalina AndrinopoulouDepartment of Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
Michael O HarhayDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0553-674X
Sarah J RatcliffeDivision of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Dimitris RizopoulosDepartment of Biostatistics, Erasmus MC, Rotterdam, The Netherlands.

Funding

R01- Mapping environmental contributions to rapid lung disease progression in cystic fibrosisR01HL141286 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2019 to 2023
$2.3M
Developing High-Quality Tools to Characterize Allograft Quality, Predict Transplant Outcomes and Expand Access to Kidney and Liver TransplantationR01DK123041 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GOLDBERG, DAVID SETH, RATCLIFFE, SARAH J · 2020 to 2023
$2.1M
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL141678NHLBI NIH HHS R01 HL141286NIDDK NIH HHS R01 DK123041
6 · The paper itself

Abstract

Individualized prediction is a hallmark of clinical medicine and decision making. However, most existing prediction models rely on biomarkers and clinical outcomes available at a single time. This is in contrast to how health states progress and how physicians deliver care, which relies on progressively updating a prognosis based on available information. With the use of joint models of longitudinal and survival data, it is possible to dynamically adjust individual predictions regarding patient prognosis. This article aims to introduce the reader to the development of dynamic risk predictions and to provide the necessary resources to support their implementation and assessment, such as adaptable R code, and the theory behind the methodology. Furthermore, measures to assess the predictive performance of the derived predictions and extensions that could improve the predictions are presented. We illustrate personalized predictions using an online dataset consisting of patients with chronic liver disease (primary biliary cirrhosis).

Indexed as

Models, StatisticalBiomarkersHumansPrognosisBiomarkersdynamic predictionsJoint modellongitudinal outcomepersonalized risk predictionssurvival outcome

Identifiers

PMID33729514
PMCPMC8783548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.