Evidence map›Paper›PMID 33729156›Full record

ArticleeLife2021

Neural representation of abstract task structure during generalization.

Avinash R Vaidya, Henry M Jones, Johanny Castillo, David Badre

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Entorhinal Cortex Signals Dimensions of Past Experience That Can Be Generalized in a Novel Environment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Hidden State Inference or Continuous Belief Updating during a Dynamic Visuomotor Skill.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
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  7. Novel Verbal Instructions Recruit Abstract Neural Patterns of Time-Variable Information Dimensionality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  16. Co-representation of Functional Brain Networks Is Shaped by Cortical Myeloarchitecture and Reveals Individual Behavioral Ability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Avinash R VaidyaDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, United States.ORCID 0000-0001-5423-5655
Henry M JonesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, United States.
Johanny CastilloDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, United States.
David BadreDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, United States.
Brown University · USAllen Institute for Brain Science · USAmherst College · US

Funding

Brown University Postbaccalaureate Research Education ProgramR25GM125500 · NIGMS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Amanda M Jamieson · 2018 to 2026
$2.6M
Brain Science Compute ClusterS10OD025181 · OD · BROWN UNIVERSITY · PI SANES, JEROME N · 2019 to 2019
$600k
Investigating the neural systems supporting memory-based decision-makingF32MH116592 · NIMH · BROWN UNIVERSITY · PI VAIDYA, AVINASH RAO · 2018 to 2020
$188k
NIGMS NIH HHS R25 GM125500NIH HHS S10 OD025181NIMH NIH HHS F32 MH116592
6 · The paper itself

Abstract

Cognitive models in psychology and neuroscience widely assume that the human brain maintains an abstract representation of tasks. This assumption is fundamental to theories explaining how we learn quickly, think creatively, and act flexibly. However, neural evidence for a verifiably generative abstract task representation has been lacking. Here, we report an experimental paradigm that requires forming such a representation to act adaptively in novel conditions without feedback. Using functional magnetic resonance imaging, we observed that abstract task structure was represented within left mid-lateral prefrontal cortex, bilateral precuneus, and inferior parietal cortex. These results provide support for the neural instantiation of the long-supposed abstract task representation in a setting where we can verify its influence. Such a representation can afford massive expansions of behavioral flexibility without additional experience, a vital characteristic of human cognition.

Indexed as

CognitionGeneralization, PsychologicalLearningBrain MappingMagnetic Resonance ImagingPrefrontal Cortexcognitiondecision-makinghumaninferencelearningneurosciencepsychologyreinforcement

Identifiers

PMID33729156
PMCPMC8016482
OpenAlexW3136669519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.