Evidence map›Paper›PMID 33728725›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022

A transgenic Alx4-CreER mouse to analyze anterior limb and nephric duct development.

Devan M Rockwell, Amber K O'Connor, Melissa R Bentley-Ford, Courtney J Haycraft, Mandy J Croyle, Kathryn M Brewer, Nicolas F Berbari, Robert A Kesterson, Bradley K Yoder

Open access · greenAbstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Devan M RockwellDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Amber K O'ConnorDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Melissa R Bentley-FordDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-9646-1420
Courtney J HaycraftDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mandy J CroyleDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kathryn M BrewerDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.
Nicolas F BerbariDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID 0000-0003-2863-1069
Robert A KestersonDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bradley K YoderDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0247-1944
University of Alabama at Birmingham · USIndiana University – Purdue University Indianapolis · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6M
UAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4M
UAB Core Center for Musculoskeletal DisordersP30AR046031 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILBERT, SHAWN ROBERT · 2001 to 2010
$5.6M
Cilia and Cystic Kidney DiseaseR01DK065655 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2004 to 2017
$4.4M
How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?R01DK114008 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Nicolas F Berbari, Jeremy F Reiter · 2018 to 2026
$3.3M
Comprehensive Training Grant in Bone Biology and DiseaseT32AR047512 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZAYZAFOON, MAJD · 2002 to 2011
$2.3M
Intraflagellar transport mediated regulation of hedgehog signalingR01HD056030 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2008 to 2012
$1.6M
Nphp4 and Bbs5 are required for ciliary mediated cell signaling events that regulate cardiac development in the mouseF31HL150898 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENTLEY, MELISSA R · 2020 to 2021
$56k
NCI NIH HHS P30 CA013148NHLBI NIH HHS F31 HL150898NIAMS NIH HHS P30 AR046031NIAMS NIH HHS T32 AR047512NICHD NIH HHS R01 HD056030NIDDK NIH HHS P30 DK074038NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P60 DK079626NIDDK NIH HHS R01 DK065655NIDDK NIH HHS R01 DK114008
6 · The paper itself

Abstract

backgroundGenetic tools to study gene function and the fate of cells in the anterior limb bud are very limited.

resultsWe describe a transgenic mouse line expressing CreER

conclusionOverall, the Alx4-CreER

Indexed as

Hedgehog ProteinsTranscription FactorsAnimalsExtremitiesHomeodomain ProteinsIntegrasesMiceMice, TransgenicTransgenesAlx4 protein, mouseHedgehog ProteinsHomeodomain ProteinsIntegrasesTranscription FactorsAristaless-like 4CreERT2fate mappinglimb bud developmentmesonephrosureteric bud

Identifiers

PMID33728725
PMCPMC8931671
OpenAlexW3137910924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.