ArticleJournal of veterinary internal medicine2021
Diagnostic evaluation of urea nitrogen/creatinine ratio in dogs with gastrointestinal bleeding.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Survival outcomes and prognostic indicators in canine pancreatitis: A retrospective cohort study of acute kidney injury and concurrent diseases.Veterinary world · 2025Article
- Alteration of clinical parameters before mortality and prognostic outcomes of pulmonary hypertension in dogs with myxomatous mitral valve disease.Open veterinary journal · 2024Article
- Rational use of gastroprotectants in cats: An evidence-based approach.Journal of feline medicine and surgery · 2024Review
- Hematological and blood biochemistry parameters as prognostic indicators of survival in canine multicentric lymphoma treated with COP and L-COP protocols.Veterinary world · 2024Article
- Plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in dogs with anaemia.Veterinary medicine and science · 2023Article
- Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs.Journal of veterinary internal medicine · 2023Article
- Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion.Journal of veterinary internal medicine · 2023Article
- Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report.BMC veterinary research · 2022Article
- Evaluation of a long-acting injectable formulation of omeprazole in healthy dogs.Journal of veterinary internal medicine · 2022Article
- Diagnostic evaluation of urea nitrogen/creatinine ratio in dogs with gastrointestinal bleeding.Journal of veterinary internal medicine · 2021Article
- Urine Neutrophil Gelatinase-Associated Lipocalin in Non-Associative Immune Mediated Hemolytic Anemia: A Prospective Controlled Study in 22 Dogs.Journal of veterinary internal medicineArticle
- Feasibility and complications of videocapsule endoscopy in dogs weighing 7 kg or less.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundUrea nitrogen/creatinine ratio (UCR) is a marker for upper gastrointestinal bleeding (GIB) in people.
objectivesTo assess the usefulness of UCR to predict occult GIB and distinguish upper from lower GIB in dogs. ANIMALS: Eighty-nine dogs with GIB and 65 clinically healthy dogs. Dogs were grouped according to 65 overt GIB and 24 occult GIB, and based on lesion localization (37 upper, 13 lower, and 8 both).
methodsSeventy-four dogs were included retrospectively and 15 dogs prospectively. Serum urea nitrogen and creatinine concentrations, UCR, hemoglobin concentration, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin concentration were compared between groups. Logistic regression models were fitted to assess if variables could distinguish occult GIB from being healthy and upper from lower GIB.
resultsThe UCR was significantly higher in dogs with overt GIB compared to control dogs (P = .02) and dogs with occult GIB (P = .05). The UCR was not significantly associated with occult GIB vs being healthy, or upper vs lower GIB (P > .05 each). Dogs with higher hemoglobin concentration and hematocrit had significantly lower odds of having occult GIB than being healthy (P < .0001 each). CONCLUSIONS AND CLINICAL IMPORTANCE: The UCR does not seem to be a clinically useful marker of occult GIB and appears to have poor discriminatory ability between upper and lower GIB. An increased UCR in a dog without signs of overt GIB, especially if its hematocrit is within the middle or upper reference interval, does not appear to warrant prompt prescription of gastrointestinal protectants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.