Evidence map›Paper›PMID 33728572›Full record

Observational studyJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

The prevalence of TTR cardiac amyloidosis among patients undergoing bone scintigraphy.

Matteo Bianco, A Parente, C Biolè, C Righetti, A Spirito, A Luciano, P Destefanis, G Nangeroni, T Angusti, M Anselmino and 1 more

Open access · greenAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Incidental Cardiac Uptake onDiseases (Basel, Switzerland) · 2026
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  18. Imagine, believe, and achieve.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Matteo BiancoDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. matteo.bianco87@gmail.com.
A ParenteDivision of Nuclear Medicine, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
C BiolèDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
C RighettiDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
A SpiritoDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
A LucianoDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
P DestefanisDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
G NangeroniDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
T AngustiDivision of Nuclear Medicine, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
M AnselminoDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza di Torino" Hospital, University of Turin, Turin, Italy.
L MontagnaDivision of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
Ospedale San Luigi Gonzaga · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiolabeled bisphosphonates bone scintigraphy is highly sensitive in detecting transthyretin (TTR) cardiac amyloidosis; data on the true prevalence of cardiac involvement in TTR amyloidosis are lacking. METHODS AND

resultsThis retrospective observational, monocentric study aims to estimate the prevalence of positive bone scan suspect for TTR cardiac amyloidosis among an all-comers population who underwent a bone scintigraphy. ECG, echocardiography and clinical status of patients with unexpected cardiac uptake (Perugini score 2-3) who underwent bone scintigraphy with [

conclusionBone scintigraphy allows suspecting TTR amyloidosis in a pre-clinical stage of the disease in an all-comers population of patients undergoing bone scintigraphy mainly for oncology reasons.

Indexed as

AgedAged, 80 and overAmyloidosisBone and BonesEchocardiographyElectrocardiographyFemaleHeartHumansMalePhenotypePrealbuminPrevalencePrognosisRadionuclide ImagingRetrospective StudiesPrealbuminTTR protein, humanAmyloidosisBone scintigraphyPerugini scoreTransthyretin

Identifiers

PMID33728572
OpenAlexW3136102571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.