ArticleInternational ophthalmology2021
Repeatability of Non-invasive Keratograph Break-Up Time measurements obtained using Oculus Keratograph 5M.
Article in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure.Scientific reports · 2024Trial
- Benchmarking Statistical, Machine Learning, and Exploratory Deep Learning Models for the Short-Term Forecasting of Monthly Aggregated Adult Ocular Surface Indicators: An Exploratory Hospital-Level Study.Diagnostics (Basel, Switzerland) · 2026Article
- Analytical Performance, Spatial Dynamics and Clinically Meaningful Change Thresholds for Automated Non-invasive Tear Film Assessment Using the Oculus Keratograph 5M.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Ocular Surface Changes and Glaucoma: A Prospective Contralateral Study of IOP-Reducing Eyedrops versus iStent Inject Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The Relationship Between Composite Inflammatory Indices and Dry Eye in Hashimoto's Disease-Induced Hypothyroid Patients.Biomedicines · 2025Article
- Agreement and repeatability of ocular surface function using the S390L Firefly WDR slitlamp compared with Keratograph 5M.Scientific reports · 2025Article
- Short-Term Changes in Tear Film Stability and Tear Volume Following the Application of Various DED Management Options in a Healthy Young Population.Journal of personalized medicine · 2025Article
- Clinical characteristics of dry eye patients with thyroid disorders: a cross-sectional study.BMC ophthalmology · 2025Article
- The repeatability of tests for dry eye signs and symptoms in the dry eye assessment and management (DREAM) study.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025Article
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- Evaluation of tear film function by Oculus Keratograph 5M and IDRA ocular surface analyser.International ophthalmology · 2024Article
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- Comparison of non-pharmaceutical treatments for evaporative dry eye: a randomised controlled study protocol.BMJ open · 2024Article
- Understanding Ocular Surface Disease in Glaucoma: A Comparative Analysis of Symptoms and Objective Parameters.Cureus · 2024Article
- Face Mask and Tear Film Stability: A Pilot Study of the Objective Measurement of Tear Break-Up Time.Journal of clinical medicine · 2023Article
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- Characteristics of the Ocular Surface in Myopic Child Candidates of Orthokeratology Lens Wear.Ophthalmology and therapy · 2023Article
- Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population: A Prospective Longitudinal Study.Journal of clinical medicine · 2023Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this study is to assess the intraexaminer repeatability of Non-invasive Keratograph Break-Up Time (NIKBUT) obtained using the Oculus Keratograph 5M (K5M), given its relevance as a homeostasis marker in Dry Eye Disease (DED).
methodsIn total, 80 healthy volunteers aged between 30 and 89 years participated. Measurements were classified according to age, sex and the presence or not of DED. Repeatability was evaluated by the calculation of within-subject standard deviation (S
resultsS
conclusionNIKBUT measurement has low intraexaminer repeatability even when considering sex, age and DED diagnosis. Nevertheless, not only is this low repeatability due to the device, but also it is largely due to the intrinsic variability of the tear film.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.