Evidence map›Paper›PMID 33728392›Full record

ArticleAPL bioengineering2021

Injectable, macroporous scaffolds for delivery of therapeutic genes to the injured spinal cord.

Arshia Ehsanipour, Mayilone Sathialingam, Laila M Rad, Joseph de Rutte, Rebecca D Bierman, Jesse Liang, Weikun Xiao, Dino Di Carlo, Stephanie K Seidlits

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Arshia EhsanipourDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.ORCID https://orcid.org/0000-0003-2007-4480
Mayilone SathialingamDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.ORCID https://orcid.org/0000-0002-6175-6472
Laila M RadDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.ORCID https://orcid.org/0000-0001-7965-7272
Joseph de RutteDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.
Rebecca D BiermanDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.
Jesse LiangDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.
Weikun XiaoDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.
Dino Di CarloORCID https://orcid.org/0000-0003-3942-4284
Stephanie K SeidlitsORCID https://orcid.org/0000-0003-3881-7166
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials are being developed as therapeutics for spinal cord injury (SCI) that can stabilize and bridge acute lesions and mediate the delivery of transgenes, providing a localized and sustained reservoir of regenerative factors. For clinical use, direct injection of biomaterial scaffolds is preferred to enable conformation to unique lesions and minimize tissue damage. While an interconnected network of cell-sized macropores is necessary for rapid host cell infiltration into-and thus integration of host tissue with-implanted scaffolds, injectable biomaterials have generally suffered from a lack of control over the macrostructure. As genetic vectors have short lifetimes

Identifiers

PMID33728392
PMCPMC7946441
OpenAlexW3133697876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.