Evidence map›Paper›PMID 33728379›Full record

ArticleExpert review of precision medicine and drug development2020

Roles of CRAC channel in cancer: implications for therapeutic development.

Husain Yar Khan, Iqra Mazahir, Shriya Reddy, Farzeen Fazili, AsfarSohail Azmi

Open access · greenAbstract read
In one paragraph

Article in Expert review of precision medicine and drug development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Anti-Inflammatory Effects of Alphitolic Acid Isolated fromInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Husain Yar KhanDepartment of Oncology, Wayne State University School of Medicine, Detroit MI 48201 USA.
Iqra MazahirDepartment of Medical Elementology and Toxicology, Jamia Hamdard, Block D, Hamdard Nagar, New Delhi, Delhi 110062, India.
Shriya ReddyDepartment of Oncology, Wayne State University School of Medicine, Detroit MI 48201 USA.
Farzeen FaziliDepartment of Oncology, Wayne State University School of Medicine, Detroit MI 48201 USA.
AsfarSohail AzmiDepartment of Oncology, Wayne State University School of Medicine, Detroit MI 48201 USA.
Wayne State University · USJamia Hamdard · IN

Funding

Clinical Translation of Nuclear Export Inhibitor in Metastatic Pancreatic CancerR37CA215427 · NCI · WAYNE STATE UNIVERSITY · PI AZMI, ASFAR S · 2018 to 2024
$2.4M
NCI NIH HHS R37 CA215427
6 · The paper itself

Abstract

introductionThe Ca2+release-activated Ca2+ (CRAC) channel, composed of Orai and STIM proteins, represents one of the main routes of Ca AREAS COVERED: In this review, we have primarily focused on the molecular composition and activation mechanism of CRAC channel as well as the myriad roles this Ca EXPERT OPINION: The possibility of targeting CRAC channel mediated Ca

Indexed as

CalciumCancer therapeuticsCRAC channelCRAC channel inhibitorOrai1STIM1Store operated Ca2+ entry

Identifiers

PMID33728379
PMCPMC7959113
OpenAlexW3048455895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.