Evidence map›Paper›PMID 33728332›Full record

Observational studyBioMed research international2021

Factors Influencing Viral Clearance in Mild COVID-19 and Clinical Characteristics of Asymptomatic Patients.

Hong-Mei Shu, Shi He, Yong Sun, Chang-Qing Lin, Yu-Fang Lu, Jing Liu, Ting Wu, Li Li, Guo-Zheng Ding, Wei Shi and 1 more

Abstract readObservational Study
In one paragraph

Observational study in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. COVID-19 patient characteristics and time to viral clearance: A retrospective observational study in a multiethnic population (United Arab Emirates).Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hong-Mei ShuDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.ORCID https://orcid.org/0000-0003-4631-9079
Shi HeDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Yong SunDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Chang-Qing LinDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Yu-Fang LuDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Jing LiuDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Ting WuDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Li LiDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Guo-Zheng DingDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Wei ShiDepartment of Respiration, Anqing Municipal Hospital, Anhui, China.
Zhen-Jun LiuInfection Disease Department, Anqing Municipal Hospital, Anhui, China.ORCID https://orcid.org/0000-0002-1397-8038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outbreak of coronavirus disease (COVID-19) has become a global public health emergency.

objectiveTo evaluate the characteristics and outcomes of patients with COVID-19 in Anhui and to identify predictors of viral clearance.

methodsWe retrospectively analyzed the data collected from discharged patients with laboratory-confirmed SARS-CoV-2 infections. We compared clinical features between viral clearance and viral persistence, and evaluated factors associated with SARS-CoV-2 shedding using multiple linear regression.

resultsAmong the 83 patients involved in the study, the median age was 43 years, while 60.2% were male, 35.4% had comorbidities, and the mortality was zero. The median time from illness onset to admission was 5 days (interquartile range (IQR), 2-7 days), and the median time from the illness onset to SARS-CoV-2 RNA detection was 16 days (IQR, 13-18 days). The factors influencing viral clearance were as follows: (1) delayed admission (beta 1.057, 95% CI 0.810-1.304;

conclusionsDelayed admission and underlying comorbidities may effectively predict SARS-CoV-2 RNA clearance. For those infected with SARS-CoV-2, even asymptomatic patients without any clinical symptoms should be traced and isolated. This practice may reduce the spread of SARS-CoV-2 and slow the COVID-19 pandemic caused by the virus.

Indexed as

AdolescentAdultAsymptomatic InfectionsComorbidityCOVID-19Disease OutbreaksFemaleHumansMaleRetrospective StudiesRNA, ViralSARS-CoV-2Virus SheddingYoung AdultRNA, Viral

Identifiers

PMID33728332
PMCPMC7936893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.