Evidence map›Paper›PMID 33728194›Full record

ReviewCureus2021

Role of Monoclonal Antibody "Alemtuzumab" in the Treatment of Multiple Sclerosis.

Sadia Nosher, Sehrish Fuad, Nupur Mishra, Zaid A Alrashid, Bindu Rathod, Devyani Mohan, Deepak M Basavanagowda, Arveen Kaur, Stacey E Heindl

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sadia NosherInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Sehrish FuadMedicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Nupur MishraMedicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Zaid A AlrashidNeurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Bindu RathodPsychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Devyani MohanSurgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Deepak M BasavanagowdaPsychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Arveen KaurPsychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Stacey E HeindlMedicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Avalon University School of Medicine · CWSpartan Health Sciences University · LCCalifornia Institute of Behavioral Neurosciences and Psychology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article will review current treatment options for multiple sclerosis (MS) while keeping our primary focus on alemtuzumab, as it is now approved in more than 65 countries. From a pathophysiological point of view, MS is a disabling disease impacting a patient's life both physically and mentally, leading to devastating social and economic impact. This review will elaborate on alemtuzumab's role in treating relapsing-remitting MS (RRMS) by comparing its efficacy, side effects, and monitoring with other disease-modifying therapies (DMTs) available in the market. It is a point of great concern not only for physicians but also for neurologists, nephrologists, endocrinologists, dermatologists, and oncologists when encountering long-term effects of alemtuzumab in the life of treated MS patients. We hope that our review will not only benefit treating faculties but also those who are suffering from this devastating disease.

Indexed as

alemtuzumabdisease-modifying therapiesimmune-mediated thrombocytopeniamultiple sclerosisnephropathysecondary autoimmune diseasesthyroid disorders

Identifiers

PMID33728194
PMCPMC7948316
OpenAlexW3127544630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.