Evidence map›Paper›PMID 33728026›Full record

ArticleOxidative medicine and cellular longevity2021

Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.

Runmin Zhao, Bingxia Wang, Dasheng Wang, Benhe Wu, Peiyu Ji, Dingyu Tan

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Isoquinoline alkaloids inChinese herbal medicines · 2026
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. The mitophagy pathway and its implications in human diseases.Signal transduction and targeted therapy · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Protective Effects of Oxyberberine in 5-Fluorouracil-Induced Intestinal Mucositis in the Mice Model.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Runmin ZhaoDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0002-6349-7494
Bingxia WangDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0001-9491-1689
Dasheng WangDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0001-7953-6622
Benhe WuDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0002-7576-7412
Peiyu JiDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0002-6111-0313
Dingyu TanDepartment of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.ORCID https://orcid.org/0000-0003-3560-2872
Northern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a serious respiratory syndrome characterized with uncontrolled inflammatory response. Oxyberberine has strong potential for clinical usage since it showed strong anti-inflammatory, antifungal, and antiarrhythmic effects in various diseases. In the present study, we evaluated whether oxyberberine can inhibit lipopolysaccharide- (LPS-) induced ALI

Indexed as

MitophagyA549 CellsAcute Lung InjuryAnimalsApoptosisBerberineBronchoalveolar Lavage FluidEdemaHumansInflammationLipopolysaccharidesLungMacrolidesMaleMiceMice, Inbred BALB Cbafilomycin A1BerberineLipopolysaccharidesMacrolidesReactive Oxygen Species

Identifiers

PMID33728026
PMCPMC7937471
OpenAlexW3134502322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.