Evidence map›Paper›PMID 33727979›Full record

ArticleBeilstein journal of organic chemistry2021

Amino- and polyaminophthalazin-1(2

Zbigniew Malinowski, Emilia Fornal, Agata Sumara, Renata Kontek, Karol Bukowski, Beata Pasternak, Dariusz Sroczyński, Joachim Kusz, Magdalena Małecka, Monika Nowak

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Reactions of 3-Hydroxy-2-phenyl-1Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zbigniew MalinowskiDepartment of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.ORCID https://orcid.org/0000-0003-1701-6271
Emilia FornalDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID https://orcid.org/0000-0002-0503-0706
Agata SumaraDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID https://orcid.org/0000-0001-8677-7379
Renata KontekDepartment of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.ORCID https://orcid.org/0000-0003-2859-9839
Karol BukowskiDepartment of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.ORCID https://orcid.org/0000-0003-2517-9898
Beata PasternakLaboratory of Molecular Spectroscopy, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.
Dariusz SroczyńskiDepartment of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.ORCID https://orcid.org/0000-0003-1146-6714
Joachim KuszInstitute of Physics, University of Silesia, 75 Pułku Piechoty 1, 41-500 Chorzów, Poland.
Magdalena MałeckaDepartment of Physical Chemistry, Theoretical and Structural Chemistry Group, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Łódź, Poland.ORCID https://orcid.org/0000-0003-3384-9855
Monika NowakDepartment of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.ORCID https://orcid.org/0000-0003-2034-5172
University of Łódź · PLMedical University of Lublin · PLInstitute of Physics · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amino- and polyaminophthalazinones were synthesized by the palladium-catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported.

Indexed as

aminationcomplexescytotoxicityPd cross-couplingphthalazinone

Identifiers

PMID33727979
PMCPMC7934800
OpenAlexW3130456736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.