Evidence map›Paper›PMID 33727977›Full record

ArticleBeilstein journal of organic chemistry2021

Menthyl esterification allows chiral resolution for the synthesis of artificial glutamate analogs.

Kenji Morokuma, Shuntaro Tsukamoto, Kyosuke Mori, Kei Miyako, Ryuichi Sakai, Raku Irie, Masato Oikawa

Abstract read
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In one paragraph

Article in Beilstein journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenji Morokuma *Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan.
Shuntaro Tsukamoto *Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan.
Kyosuke MoriYokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan.
Kei MiyakoFaculty of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan.
Ryuichi SakaiFaculty of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan.
Raku IrieYokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan.
Masato OikawaYokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan.ORCID https://orcid.org/0000-0002-3919-811X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report the enantiospecific synthesis of two artificial glutamate analogs designed based on IKM-159, an antagonist selective to the AMPA-type ionotropic glutamate receptor. The synthesis features the chiral resolution of the carboxylic acid intermediate by the esterification with ʟ-menthol, followed by a configurational analysis by NMR, conformational calculation, and X-ray crystallography. A mice in vivo assay showed that (2

Indexed as

chiral resolutionconfigurational analysisglutamatemetathesisneuroactivity

Identifiers

PMID33727977
PMCPMC7934734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.