Evidence map›Paper›PMID 33727854›Full record

ReviewPharmacogenomics and personalized medicine2021

Tackling Drug Resistance in EGFR Exon 20 Insertion Mutant Lung Cancer.

Laura Pacini, Andrew D Jenks, Simon Vyse, Christopher P Wilding, Amani Arthur, Paul H Huang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Current paradigm of EGFRMed (New York, N.Y.) · 2025
    Review
  4. Prevalence ofTranslational lung cancer research · 2025
    Article
  5. Article
  6. Review
  7. [EGFR Exon 20 Insertion Mutation: Research Status and New Treatment Strategies].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Advances in the management of non-small-cell lung cancer harbouringTherapeutic advances in medical oncology · 2023
    Review
  12. Article
  13. Cancers · 2022
    Review
  14. Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Frontiers in pharmacology · 2021
    Article
  20. TargetingCancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laura Pacini *Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Andrew D Jenks *Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Simon Vyse *Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Christopher P WildingDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Amani ArthurDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Paul H HuangDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Institute of Cancer Research · GB

Funding

Cancer Research UK 19281
6 · The paper itself

Abstract

Insertion mutations in exon 20 (Ex20ins) of the epidermal growth factor receptor (

Indexed as

drug resistanceEGFRexon 20 insertionslung cancerpoziotinibPROTACs

Identifiers

PMID33727854
PMCPMC7955704
OpenAlexW3135804416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.