ArticleInternational journal of nephrology and renovascular disease2021
Structural and Functional Brain Changes in Hemodialysis Patients with End-Stage Renal Disease: DTI Analysis Results and ALFF Analysis Results.
Article in International journal of nephrology and renovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Altered brain activity in patients with end-stage renal disease: A meta-analysis of resting-state functional imaging.Brain and behavior · 2023Pooled it
- Alterations of amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations in end-stage renal disease on maintenance dialysis: An activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2022Pooled it
- Exploring the role of quantitative susceptibility mapping in assessing brain iron deposition in hemodialysis patients.Insights into imaging · 2026Article
- Associations between sleep quality, excessive daytime sleepiness, and theta wave activity during resting-state electroencephalography in maintenance hemodialysis patients.International urology and nephrology · 2025Article
- Analysis of the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis patients: a prospective longitudinal study.Renal failure · 2025Article
- Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Brain surface area and function alterations are correlated with cognition in patients with end-stage renal disease.Quantitative imaging in medicine and surgery · 2025Article
- Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis.Annals of medicine · 2024Article
- Combination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.CNS neuroscience & therapeutics · 2024Article
- Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease.International urology and nephrology · 2024Article
- Altered spontaneous brain activities in maintenance hemodialysis patients with cognitive impairment and the construction of cognitive function prediction models.Renal failure · 2023Article
- Association of aberrant structural-functional network coupling with cognitive decline in patients with non-dialysis-dependent stage 5 chronic kidney disease.Quantitative imaging in medicine and surgery · 2023Article
- Altered Resting-State Functional Networks in Nondialysis Patients with Stage 5 Chronic Kidney Disease: A Graph-Theoretical Analysis.Brain sciences · 2023Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- K-Means Clustering Algorithm-Based Functional Magnetic Resonance for Evaluation of Regular Hemodialysis on Brain Function of Patients with End-Stage Renal Disease.Computational and mathematical methods in medicine · 2022Article
- Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease.Frontiers in neurology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe current study aimed to depict intrinsic structural changes and the spontaneous brain activity patterns in voxel level in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) by using diffusion-tensor imaging and resting-state functional magnetic resonance (MR) imaging with an amplitude of low-frequency fluctuations (ALFF) algorithm and their clinical relevance. MATERIALS AND
methodsIn the study, the diffusion-tensor imaging and resting-state functional MR imaging were performed in forty-two hemodialysis patients with ESRD and 42 healthy control subjects. Neuropsychological and laboratory tests were performed in all subjects. ALFF, fraction anisotropy (FA), and mean diffusivity (MD) values were compared between the two groups. Correlations between ALFF, FA or MD values, and clinical markers were analyzed.
resultsWe found that ESRD patients exhibited significantly lower ALFF values in multiple areas, including medial frontal gyrus, limbic lobe, superior frontal gyrus, bilateral lingual gyri, occipital lobe, parahippocampal gyrus, precuneus, while increased ALFF values in medial frontal gyrus than healthy controls. FA values were decreased in medial frontal gyrus, parietal lobe, and left precuneus regions in the ESRD group compared with controls. Importantly, FA for the frontal and parietal lobes was negatively associated with the dialysis duration of ESRD patients, ALFF z-scores for the medial prefrontal cortex (MPFC) were positively correlated with the dialysis duration of ESRD patients and Serum calcium of ESRD patients negatively correlated with FA values in the frontal and parietal lobes (
conclusionOur study revealed that both impaired brain structure and function in ESRD patients with routine hemodialysis distributed mainly in the parietal, temporal, and frontal lobes. ESRD patients have cognitive impairment and declined memory ability. Serum calcium and dialysis duration might be associated with the impairment of brain structure and function in patients with ESRD.
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