Evidence map›Paper›PMID 33727848›Full record

ArticleJournal of inflammation research2021

Possible Role of Regulatory B Cells in Different Behçet's Disease Phenotypes and Therapies: First Report from Egypt.

Helal F Hetta, Alaa A A Mohamed, Asmaa M Zahran, Safaa A Mahran, Marwa My Sayed, Mohamed Ga Saleh, Khaled Abdelazeem, Gaber El-Saber Batiha, Salim Al-Rejaie, Yasir Waheed and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Genetics in Behcet's Disease: An Update Review.Frontiers in ophthalmology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Helal F Hetta *Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-8541-7304
Alaa A A Mohamed *Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-5758-3428
Asmaa M Zahran *Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Safaa A MahranRheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Marwa My SayedDepartment of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed Ga SalehDepartment of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Khaled AbdelazeemDepartment of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicines, Damanhour University, Damanhur, 22511, Egypt.
Salim Al-RejaieDepartment of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Yasir WaheedFoundation University Medical College, Foundation University Islamabad, Islamabad, 44000, Pakistan.
Khalid MuhammadDepartment of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab Emirates.
Manal M HassanienRheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Assiut University · EGDamanhour University · EGFoundation University Islamabad · PKKing Saud University · SAUnited Arab Emirates University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe data about the role of regulatory B cells (Breg) in Behcet Disease (BD) are scarce. We aimed to evaluate the frequency of total B lymphocytes and Breg cells in different BD phenotypes and therapies attempting to unravel their function.

methodsThis cross-sectional study included 35 BD patients and 39 healthy controls (HCs). The demographic data of the study subjects were collected including age and gender. Current medications including disease-modifying anti-rheumatic drugs (DMARDs) were recorded. All patients underwent testing for baseline laboratory investigations including full blood count, liver and kidney function tests, erythrocyte sedimentation rate (ESR) by Westergren blot and C-reactive protein (CRP). Measurement of the total B lymphocytes and their subtypes B regulatory lymphocytes by flow cytometric assay. Assessment of BD activity was done using the revised Behçet's Disease Current Activity Form (BDCAF) 2006 and Behçet's Syndrome Activity Score (BSAS)

resultsA dramatic drop in the number of B cells, total and regulatory, was observed in the patients compared to the HCs. Regulatory cells (Bregs) tend to be upregulated with genital ulcers or vascular disease. Bregs but not B lymphocytes were associated with BSAS and ESR. Neither the total B lymphocytes nor the Bregs correlated with CRP or the sexual function or depression scores. Of all the used medications, low-dose aspirin was seen with markedly high Bregs proportions.

conclusionThis study supports the role of B cells in BD pathogenesis and strongly suggests a possible role for Bregs in the resolution of different BD manifestations.

Indexed as

Behcet’s diseaseB lymphocytesBreg

Identifiers

PMID33727848
PMCPMC7955029
OpenAlexW3134287774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.