Evidence map›Paper›PMID 33727709›Full record

ReviewNature reviews. Endocrinology2021

Hormonal regulation of biomineralization.

Andrew Arnold, Elaine Dennison, Christopher S Kovacs, Michael Mannstadt, René Rizzoli, Maria Luisa Brandi, Bart Clarke, Rajesh V Thakker

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Andrew ArnoldDivision of Endocrinology & Metabolism and Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT, USA. aarnold@uchc.edu.ORCID http://orcid.org/0000-0002-8821-8527
Elaine DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Christopher S KovacsFaculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, Canada.ORCID http://orcid.org/0000-0002-5219-9993
Michael MannstadtEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
René RizzoliDivision of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Maria Luisa BrandiDepartment of Biochemical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
Bart ClarkeMayo Clinic Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-3801-9546
Rajesh V ThakkerAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1438-3220
Harvard University · USMayo Clinic in Arizona · USMemorial University of Newfoundland · CAMRC Lifecourse Epidemiology Unit · GBUniversity Hospital of Geneva · CHUniversity of Connecticut · USUniversity of Florence · ITUniversity of Oxford · GB

Funding

CIHRDepartment of HealthWellcome Trust
6 · The paper itself

Abstract

Biomineralization is the process by which organisms produce mineralized tissues. This crucial process makes possible the rigidity and flexibility that the skeleton needs for ambulation and protection of vital organs, and the hardness that teeth require to tear and grind food. The skeleton also serves as a source of mineral in times of short supply, and the intestines absorb and the kidneys reclaim or excrete minerals as needed. This Review focuses on physiological and pathological aspects of the hormonal regulation of biomineralization. We discuss the roles of calcium and inorganic phosphate, dietary intake of minerals and the delicate balance between activators and inhibitors of mineralization. We also highlight the importance of tight regulation of serum concentrations of calcium and phosphate, and the major regulators of biomineralization: parathyroid hormone (PTH), the vitamin D system, vitamin K, fibroblast growth factor 23 (FGF23) and phosphatase enzymes. Finally, we summarize how developmental stresses in the fetus and neonate, and in the mother during pregnancy and lactation, invoke alternative hormonal regulatory pathways to control mineral delivery, skeletal metabolism and biomineralization.

Indexed as

BiomineralizationBone and BonesFibroblast Growth Factor-23HumansMineralsFGF23 protein, humanFibroblast Growth Factor-23Minerals

Identifiers

PMID33727709
OpenAlexW3137521578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.