SynthesisScientific reports2021
Clinical consequences of head and neck free-flap reconstructions in the DM population.
Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Early Complications in Mandibular Reconstruction: Analysis Using Comprehensive Complication Index.Journal of surgical oncology · 2026Article
- Risk Factors for Free Flap Failure in Head and Neck Reconstruction: A Retrospective Analysis From a Single Medical Center.Plastic and reconstructive surgery. Global open · 2026Article
- Microsurgical reconstruction in midface defects based on defect morphology and size - Reconstruction techniques, complications, and outcomes.Oral and maxillofacial surgery · 2026Article
- Complications of Metabolic Dysfunction in Head and Neck Microvascular Reconstruction.Laryngoscope investigative otolaryngology · 2025Article
- Antibiotic Prophylaxis in Patients Undergoing Oncologic Head and Neck Surgery with Free Flap Reconstruction: Still a Matter of Debate.Antibiotics (Basel, Switzerland) · 2025Review
- Preventing Free Flap Complications: Key Factors to Keep in Mind.Journal of surgical oncology · 2025Article
- Microvascular free flaps in head and neck reconstruction: an analysis of outcomes in elderly patients.Clinical oral investigations · 2025Article
- The Extracellular Matrix Promotes Diabetic Oral Wound Healing by Modulating the Microenvironment.Biomaterials research · 2025Article
- Review
- Risk Factors of Free Flap Complications in Reconstruction for Head and Neck Cancer.Yonago acta medica · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is a common comorbidity and risk factor for postoperative complications in head and neck (H&N) microsurgical reconstructions. Our study focused on the association between DM and individual complications regarding both surgical and medical aspects. A meta-analysis of English-language articles comparing a series of complications between DM and non-DM H&N free-flap recipients was performed by comprehensive meta-analysis (CMA). Twenty-seven articles presented 14,233 H&N free-flap reconstructions, and a subset of 2329 analyses including diabetic cases was included for final analysis. Total postoperative (RR = 1.194, p < 0.001; OR = 1.506, p = 0.030) and surgical (RR = 1.550, p = 0.001; OR = 3.362, p < 0.001) complications were increased in DM subjects. Free-flap failure/necrosis (RR = 1.577, p = 0.001; OR = 1.999, p = 0.001) and surgical site infections (OR = 2.414, p < 0.001) were also increased in diabetic recipients. However, return to the operating room, dehiscence, fistulas, plate exposures, readmissions, and mortalities were not increased in DM patients. DM increased various complications in H&N free-flap reconstructions. Surgical indications should be cautiously evaluated, and aggressive treatments should be implemented for high-risk recipients.
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