ArticleScientific reports2021
Clinical and genomic features of Corynebacterium macginleyi-associated infectious keratitis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
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- Ocular community state types reveal distinct microbial compositions among microbiomes with implications for trachoma control.bioRxiv : the preprint server for biology · 2026Article
- Blepharitis driven by microbiome dysbiosis andFrontiers in medicine · 2026Review
- Genomic and phenotypic diversity among taxonomically ambiguous clinical Corynebacterium isolates.BMC microbiology · 2025Article
- Article
- Incidence, risk factors, and patient characteristics in severe contact lens-related microbial keratitis.Acta ophthalmologica · 2025Article
- Clinical and bacteriological characteristics of Corynebacterium keratitis.Journal of ophthalmic inflammation and infection · 2025Article
- Whole genome sequencing and characterization of Corynebacterium isolated from the healthy and dry eye ocular surface.BMC microbiology · 2024Article
- Relationship Between Fluoroquinolone Resistance and Mutations in the Quinolone Resistance-Determining Region in Corynebacterium macginleyi.Investigative ophthalmology & visual science · 2024Article
- Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience.Microorganisms · 2023Article
- Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects.Frontiers in cellular and infection microbiology · 2022Article
- Complete Genome Sequences of Two Corynebacterium macginleyi Strains Isolated from Infectious Keratitis.Microbiology resource announcements · 2021Article
- Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome.Frontiers in cellular and infection microbiology · 2021Article
- Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the GenusFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infectious keratitis is a potentially sight threatening ophthalmological emergency. Contact lens wear is a common risk factor. Diagnostic advances such as MALDI-TOF MS provides new insights into the spectrum of corneal pathogens and on microbes previously considered as commensals. Corynebacterium macginleyi was described in 1995, and in 2018, the genomic features of three isolates were reported after whole-genome sequencing. Here we describe the clinical characteristics of patients with infectious keratitis (n = 29) presumably caused by Corynebacterium macginleyi, and analyze the genomic features of C. macginleyi (n = 22) isolated from the corneal ulcers of these patients. The disease course was uneventful apart from minor interventions such as corneal cross-linking and amniotic membrane transplant. Genome sequencing and comparison revealed a highly conserved core genome of C. macginleyi. Based on the analyses of single nucleotide polymorphisms, the population could be divided into two main clades that also differed in a few clade-specific genomic islands. Patients infected with an isolate belonging to the minor clade (n = 7) presented a more severe disease. Comparisons with other corynebacterial species clearly separated C. macginleyi. C. macginleyi may be considered a corneal pathogen; genomic analysis provided insights into its population structure and disease-causing potential.
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