Evidence map›Paper›PMID 33727417›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging.

Friederike Hesse, Vencel Somai, Felix Kreis, Flaviu Bulat, Alan J Wright, Kevin M Brindle

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Potential Clinical Applications of HyperpolarizedRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  11. Use of Nuclear Magnetic Resonance (NMR) to Study Cancer Metabolism.Advances in experimental medicine and biology · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. In vivoMagnetic resonance in medicine · 2025
    Article
  16. Article
  17. Article
  18. A Genetically Engineered Reporter System Designed forJournal of the American Chemical Society · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Friederike HesseCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0001-5427-7564
Vencel SomaiCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0001-9874-526X
Felix KreisDepartment of Information Technology and Electrical Engineering, ETH Zürich, 8092 Zürich, Switzerland.ORCID 0000-0003-3340-3861
Flaviu BulatCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.
Alan J WrightCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0002-4577-5681
Kevin M BrindleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom; kmb1001@cam.ac.uk.ORCID 0000-0003-3883-6287
University of Cambridge · GBETH Zurich · CH

Funding

Cancer Research UK 17242Cancer Research UK 28289Cancer Research UK C197/A16465Cancer Research UK C197/A17242Cancer Research UK C9685/A25177
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell DeathMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMolecular ImagingAnimalsBiomarkersCell Line, TumorDeuteriumDisease Models, AnimalFumaratesHeterograftsHumansImmunohistochemistryMiceBiomarkersDeuteriumFumaratescell deathdeuteriumMRItumor

Identifiers

PMID33727417
PMCPMC8000230
OpenAlexW3139087730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.