Evidence map›Paper›PMID 33727398›Full record

ArticlemSystems2021

Mitochondrion-Dependent Apoptosis Is Essential for Rickettsia parkeri Infection and Replication in Vector Cells.

Xin-Ru Wang, Nicole Y Burkhardt, Timothy J Kurtti, Jonathan D Oliver, Lisa D Price, Benjamin Cull, Cody J Thorpe, Michalina Silva Thiel, Ulrike G Munderloh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Infection and immunity · 2025
    Article
  6. Microbiology spectrum · 2025
    Article
  7. Article
  8. Article
  9. Cells · 2023
    Article
  10. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
  11. Lock and Key: WhyPathogens (Basel, Switzerland) · 2022
    Article
  12. Apoptosis and Autophagy: Current Understanding in Tick-Pathogen Interactions.Frontiers in cellular and infection microbiology · 2022
    Review
  13. TheFrontiers in veterinary science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xin-Ru WangDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA wang8848@umn.edu munde001@umn.edu.ORCID https://orcid.org/0000-0002-9692-865X
Nicole Y BurkhardtDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Timothy J KurttiDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Jonathan D OliverSchool of Public Health, Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8738-112X
Lisa D PriceDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Benjamin CullDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Cody J ThorpeDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Michalina Silva ThielDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Ulrike G MunderlohDepartment of Entomology, University of Minnesota, St. Paul, Minnesota, USA wang8848@umn.edu munde001@umn.edu.
University of Minnesota · US

Funding

Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
NIAID NIH HHS R01 AI049424
6 · The paper itself

Abstract

Apoptosis is an innate immune response induced by infection in eukaryotes that contributes significantly to protection from pathogens. However, little is known about the role of apoptosis in the interactions of arthropod vectors with the rickettsiae that they transmit.

Indexed as

apoptosismitochondriaRickettsiaRickettsia pathogenesisticktick-borne pathogens

Identifiers

PMID33727398
PMCPMC8546998
OpenAlexW3136682594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.