Evidence map›Paper›PMID 33727339›Full record

ArticleSexually transmitted infections2022

Sexual behaviours associated with incident high-risk anal human papillomavirus among gay and bisexual men.

Ian K J Wong, Isobel Mary Poynten, Alyssa Cornall, David J Templeton, Monica Molano, Suzanne M Garland, Christopher K Fairley, Carmella Law, Richard J Hillman, Mark N Polizzotto and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Acceptability of an Anal Cancer Screening Chatbot Among High-Risk Men Undergoing Community-Based Screening.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
  4. Article
  5. Review
  6. Inconsistent condom use with casual partners among men who have sex with men in Brazil: a cross-sectional study.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023
    Article
  7. Article
  8. How Much Does HIV Positivity Affect the Presence of Oral HPV? A Molecular Epidemiology Survey.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Ian K J WongThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia iwong@kirby.unsw.edu.au.ORCID 0000-0001-8206-4101
Isobel Mary PoyntenThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia.
Alyssa CornallDepartment of Obstetrics and Gynaecology, University of Melbourne, Infection & Immunity, The Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
David J TempletonThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia.
Monica MolanoCentre for Women's Infectious Disease, The Royal Women's Hospital, Melbourne, Victoria, Australia.
Suzanne M GarlandDepartment of Obstetrics and Gynaecology, University of Melbourne, Infection & Immunity, The Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Melbourne, Victoria, Australia.ORCID 0000-0001-9081-1664
Carmella LawHIV and Immunology, St Vincent's Hospital, Sydney, New South Wales, Australia.
Richard J HillmanHIV and Immunology, St Vincent's Hospital, Sydney, New South Wales, Australia.
Mark N PolizzottoThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia.
Andrew E GrulichThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia.
Fengyi JinThe Kirby Insitute, UNSW Sydney, Sydney, New South Wales, Australia.
SPANC study team
UNSW Sydney · AURoyal Women's Hospital · AUSt. Vincent's Birmingham · USMelbourne Sexual Health Centre · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHigh-risk human papillomavirus (HRHPV) causes anal cancer, which disproportionately affects gay and bisexual men (GBM). We examined sexual behaviours associated with incident anal HRHPV in an observational cohort study of GBM in Sydney, Australia.

methodsGBM aged 35 years and above were enrolled in the Study of the Prevention of Anal Cancer. Detailed information on sexual practices in the last 6 months, including receptive anal intercourse (RAI) and non-intercourse receptive anal practices, was collected. Anal human papillomavirus (HPV) testing was performed at the baseline and three annual follow-up visits. Risk factors for incident HRHPV were determined by Cox regression using the Wei-Lin-Weissfeld method.

resultsBetween 2010 and 2015, 617 men were recruited and 525 who had valid HPV results at baseline and at least one follow-up visit were included in the analysis. The median age was 49 years (IQR 43-56) and 188 (35.8%) were HIV-positive. On univariable analysis, incident anal HRHPV was associated with being HIV-positive (p<0.001), having a higher number of recent RAI partners regardless of condom use (p<0.001 for both), preference for the receptive position during anal intercourse (p=0.014) and other non-intercourse receptive anal sexual practices, including rimming, fingering and receptive use of sex toys (p<0.05 for all). In multivariable analyses, being HIV-positive (HR 1.46, 95% CI 1.09 to 1.85, p=0.009) and reporting condom-protected RAI with a higher number of sexual partners (p<0.001) remained significantly associated with incident HRHPV. When stratified by recent RAI, non-intercourse receptive anal practices were not associated with incident HRHPV in men who reported no recent RAI.

conclusionGBM living with HIV and those who reported RAI were at increased of incident anal HRHPV. Given the substantial risk of anal cancer and the difficulty in mitigating the risk of acquiring anal HRHPV, HPV vaccination should be considered among sexually active older GBM. TRIAL REGISTRATION NUMBER: ANZCTR365383.

Indexed as

AdultAlphapapillomavirusAnal CanalAnus NeoplasmsCohort StudiesHomosexuality, MaleHumansMaleMiddle AgedPapillomavirus InfectionsRisk FactorsSexual and Gender MinoritiesSexual Behaviorcohort studieshomosexualitymalepapillomaviridaerisk factors

Identifiers

PMID33727339
PMCPMC8862078
OpenAlexW3139176889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.