Evidence map›Paper›PMID 33727332›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.

Luke Grundy, Ashlee Caldwell, Sonia Garcia-Caraballo, David Grundy, Nick J Spencer, Xinzhong Dong, Joel Castro, Andrea M Harrington, Stuart M Brierley

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. MrgprC11 expression and function in vagal afferent nerves in the esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  3. Review
  4. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  5. A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025
    Article
  6. Diabetic neuropathy: cutting-edge research and future directions.Signal transduction and targeted therapy · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Luke GrundyVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia.
Ashlee CaldwellVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia.
Sonia Garcia-CaraballoVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia.
David GrundyDepartment of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom.
Nick J SpencerVisceral Neurophysiology Laboratory, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, 5042 South Australia, Australia.ORCID 0000-0003-2190-5303
Xinzhong DongSolomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, 21205 Maryland.
Joel CastroVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia.
Andrea M HarringtonVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia.
Stuart M BrierleyVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia stuart.brierley@flinders.edu.au.ORCID 0000-0002-2527-2905
Flinders University · AUHoward Hughes Medical Institute · USUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the sensory mechanisms innervating the bladder is paramount to developing efficacious treatments for chronic bladder hypersensitivity conditions. The contribution of Mas-gene-related G protein-coupled receptors (Mrgpr) to bladder signaling is currently unknown. Using male and female mice, we show with single-cell RT-PCR that subpopulations of DRG neurons innervating the mouse bladder express

Indexed as

AnimalsFemaleGanglia, SpinalLumbosacral PlexusMaleMiceMice, Inbred C57BLMice, KnockoutNeurons, AfferentPatch-Clamp TechniquesPhysical StimulationPosterior Horn CellsReceptors, G-Protein-CoupledTRPV Cation ChannelsUrinary BladderMrgprA3 protein, mouseMrgprx1 protein, mouseReceptors, G-Protein-CoupledTRPV1 protein, mouseTRPV Cation ChannelsbladderGPCRitchpainsensory neuronsvisceral afferents

Identifiers

PMID33727332
PMCPMC8084315
OpenAlexW3136283867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.