ArticleCancer imaging : the official publication of the International Cancer Imaging Society2021
Application of diffusion kurtosis tensor MR imaging in characterization of renal cell carcinomas with different pathological types and grades.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Motion and Flow Robust Free-Breathing Diffusion Kurtosis Imaging of the Kidney.NMR in biomedicine · 2025Article
- Advances in renal cancer: diagnosis, treatment, and emerging technologies.La Radiologia medica · 2025Review
- Diffusion kurtosis versus diffusion-weighted magnetic resonance imaging in differentiating clear cell renal cell carcinoma and renal angiomyolipoma with minimal fat: a comparative study.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Renal oncocytoma mimicking chromophobe renal cell carcinoma: Management using proposed diagnostic algorithm with emphasis on 99mTc-sestamibi SPECT/CT.Intractable & rare diseases research · 2025Article
- Multisequence combined magnetic resonance imaging radiomics model to noninvasively predict nuclear grade of clear cell renal cell carcinoma: interpretable model development.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Diagnostic performance of multiparametric magnetic resonance imaging in the differentiation of clear cell renal cell cancer.Abdominal radiology (New York) · 2023Article
- WHO/ISUP grade and pathological T stage of clear cell renal cell carcinoma: value of ZOOMit diffusion kurtosis imaging and chemical exchange saturation transfer imaging.European radiology · 2023Article
- Review
- Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging.PloS one · 2023Article
- Diffusion weighted imaging and diffusion kurtosis imaging in abdominal oncological setting: why and when.Infectious agents and cancer · 2022Review
- Diffusion-Weighted MRI in the Genitourinary System.Journal of clinical medicine · 2022Review
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo probe the feasibility and reproducibility of diffusion kurtosis tensor imaging (DKTI) in renal cell carcinoma (RCC) and to apply DKTI in distinguishing the subtypes of RCC and the grades of clear cell RCC (CCRCC).
methodsThirty-eight patients with pathologically confirmed RCCs [CCRCC for 30 tumors, papillary RCC (PRCC) for 5 tumors and chromophobic RCC (CRCC) for 3 tumors] were involved in the study. Diffusion kurtosis tensor MR imaging were performed with 3 b-values (0, 500, 1000s/mm
resultsInter-observer measurements for each metric showed great reproducibility with excellent ICCs ranging from 0.81 to 0.87. There were significant differences between the DKTI metrics of RCCs and contralateral renal parenchyma, also among the subtypes of RCC. MK and Ka values of CRCC were significantly higher than those of CCRCC and PRCC. Statistical difference of the MK, Ka, Kr and MD values were also obtained between CCRCC with high- and low-grades. MK values were more effective for distinguishing between low- and high- grade CCRCC (area under the ROC curve: 0.949). A threshold value of 0.851 permitted distinction with high sensitivity (90.9%) and specificity (87.5%).
conclusionOur preliminary results suggest a possible role of DKTI in differentiating CRCC from CCRCC and PRCC. MK, the principle DKTI metric might be a surrogate biomarker to predict nuclear grades of CCRCC.
trial registrationChiCTC, ChiCTR-DOD-17010833, Registered 10 March, 2017, retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=17559 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.