Evidence map›Paper›PMID 33726769›Full record

ArticleThrombosis journal2021

Viscoelastometry for detecting oral anticoagulants.

Philipp Groene, Daniela Wagner, Tobias Kammerer, Lars Kellert, Andreas Giebl, Steffen Massberg, Simon Thomas Schäfer

Open access · goldAbstract read
In one paragraph

Article in Thrombosis journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Viscoelastic monitoring of direct oral anticoagulants (DOAC).Blood transfusion = Trasfusione del sangue · 2025
    Article
  8. Article
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  12. Recent advancements in critical care: Part I.Indian journal of anaesthesia · 2023
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Philipp GroeneDepartment of Anaesthesiology, University Hospital Munich, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. philipp.groene@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-8357-5552
Daniela WagnerDepartment of Anaesthesiology, University Hospital Munich, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Tobias KammererDepartment of Anaesthesiology, University Hospital Munich, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Lars KellertDepartment of Neurology, University Hospital Munich, LMU Munich, Munich, Germany.
Andreas GieblDepartment of Transfusion Medicine and Hemostaseology, University Hospital Augsburg, Augsburg, Germany.
Steffen MassbergDepartment of Internal Medicine I - Cardiology, University Hospital Munich, LMU Munich, Munich, Germany.
Simon Thomas SchäferDepartment of Anaesthesiology, University Hospital Munich, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
LMU Klinikum · DEUniversity Hospital Augsburg · DE

Funding

enicor GmbH Thromboelastometric machines and reagents were provided by enicor GmbH (Munich, Germany).
6 · The paper itself

Abstract

backgroundDetermination of anticoagulant therapy is of pronounced interest in emergency situations. However, routine tests do not provide sufficient insight. This study was performed to investigate the impact of anticoagulants on the results of viscoelastometric assays using the ClotPro device.

methodsThis prospective, observational study was conducted in patients receiving dabigatran, factor Xa (FXa)-inhibitors, phenprocoumon, low molecular weight heparin (LMWH) or unfractionated heparin (UFH) (local ethics committee approval number: 17-525-4). Healthy volunteers served as controls. Viscoelastometric assays were performed, including the extrinsic test (EX-test), intrinsic test (IN-test) Russel's viper venom test (RVV-test), ecarin test (ECA-test), and the tissue plasminogen activator test (TPA-test).

results70 patients and 10 healthy volunteers were recruited. Clotting time in the EX-test (CT

conclusionsIn emergency situations, ClotPro viscoelastometric assessment of whole-blood samples may help towards determining the presence and type of anticoagulant class that a patient is taking.

trial registrationGerman clinical trials database ID: DRKS00015302 .

Indexed as

AnticoagulantsCoagulation testsDabigatranFactor Xa (FXa) inhibitorsHeparinViscoelastometry

Identifiers

PMID33726769
PMCPMC7962229
OpenAlexW3136230461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.