ReviewWorld journal of surgical oncology2021
Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma: case report and literature review.
Review in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Heterogeneous Intermediate Phenotypes of Cancer Cells with Varying Ki-67-Positivity Rates, Including Histologically HCC-like and NEC-like Cells, in Liver MiNEN.International journal of molecular sciences · 2026Article
- Rapid Progression of Primary Hepatic Neuroendocrine Carcinoma: A Case Report Demonstrating Drastic Oncological Behavior.The American journal of case reports · 2025Article
- Primary hepatic neuroendocrine tumor with a suspicious pulmonary nodule: A case report and literature review.World journal of clinical oncology · 2025Article
- Review
- Primary giant hepatic neuroendocrine neoplasms in a young adult: case report and literature review.Frontiers in oncology · 2025Article
- Diagnostic value of serum vascular endothelial growth factor and interleukin-17 in primary hepatocellular carcinoma.World journal of gastrointestinal surgery · 2024Article
- Hepatocellular carcinoma‑cavernous hemangioma collision tumor: A case report.Oncology letters · 2024Article
- Interventional Combined Microwave Ablation for Primary Neuroendocrine Carcinoma of the Liver Failing Systemic Chemotherapy: A Case Report.Journal of hepatocellular carcinoma · 2024Article
- Synchronous Double Primary Tumors of Liver (Small Cell Neuroendocrine Carcinoma and Hepatocellular carcinoma): A Case Report.Hepatic medicine : evidence and research · 2024Article
- Combined Hepatocellular Neuroendocrine Carcinoma: A Rare Tumor.ACG case reports journal · 2023Article
- Mixed Primary Hepatocellular Carcinoma and Hepatic Neuroendocrine Carcinoma: Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- Mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver.Cancer reports (Hoboken, N.J.) · 2023Article
- Case report: mixed large-cell neuroendocrine and hepatocellular carcinoma of the liver.Frontiers in oncology · 2023Article
- Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report.World journal of clinical cases · 2022Article
- Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case.Internal medicine (Tokyo, Japan) · 2022Article
- Mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal system: An update.World journal of gastroenterology · 2022Review
- Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature.Frontiers in surgery · 2022Article
- Artificial Intelligence Algorithm in Classification and Recognition of Primary Hepatic Carcinoma Images under Magnetic Resonance Imaging.Contrast media & molecular imaging · 2022Article
- Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report.Communications medicine · 2022Article
- Primary Hepatic Neuroendocrine Carcinoma with Metastasis to the Mesentery: A Case Report.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) can grow in a mosaic pattern, often combined with various non-hepatocellular cells. However, HCC combined with a neuroendocrine carcinoma (NEC) component is rarely reported, and its clinical features, origin, diagnosis, and behavior have not been established. In the literature, mixed HCC-NEC tumors are categorized as either collision type or combined type, depending on their microscopic features. Here, we report a patient with a combined-type HCC-NEC tumor. CASE PRESENTATION: An asymptomatic 84-year-old woman was found to have a solid mass in the right lobe of the liver. Laboratory and radiologic examinations showed typical findings of HCC, including arterial-phase enhancement, and portal- and delay-phase washout. She was treated by partial laparoscopic hepatectomy of segment 5. Pathological examination showed that the tumor was predominantly HCC, partly admixed with an NEC component. A transitional zone between the HCC and NEC tissues was also observed. The tumor was finally diagnosed as a combined-type primary mixed NEC-HCC tumor. After the preoperative diagnosis, the patient underwent somatostatin receptor scintigraphy to detect the primary NEC lesion, but no accumulation was found in any other part of her body. She has been free of recurrence for 9 months since the surgery.
conclusionMixed HCC-NEC tumors are extremely rare, and correct diagnosis requires multidisciplinary collaboration. The accumulation of further cases is needed to help understand the exact pathology, diagnosis, and treatment of this disease.
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