Evidence map›Paper›PMID 33726684›Full record

Observational studyBMC cancer2021

Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe.

Stanie Gaete, Aviane Auguste, Bernard Bhakkan, Jessica Peruvien, Cecile Herrmann-Storck, Youri Socrier, Abdoulaye Diedhiou, Jacqueline Deloumeaux

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stanie GaeteBiological Resources Center Karubiotec™, BRIF n° KARUBIOTEC-GUA-00971, Pointe-à-Pitre, Guadeloupe.
Aviane AugusteGuadeloupe cancer registry, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe.
Bernard BhakkanGuadeloupe cancer registry, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe.
Jessica PeruvienGuadeloupe cancer registry, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe.
Cecile Herrmann-StorckVirology-Microbiology Unit, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe.
Youri SocrierPathology Laboratory ALIZES, Baie-Mahault, Guadeloupe.
Abdoulaye DiedhiouPathology Laboratory, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe.
Jacqueline DeloumeauxBiological Resources Center Karubiotec™, BRIF n° KARUBIOTEC-GUA-00971, Pointe-à-Pitre, Guadeloupe. jacqueline.deloumeaux@chu-guadeloupe.fr.ORCID https://orcid.org/0000-0001-7841-3313
Centre Hospitalier Universitaire Pointe-à-Pitre · GPInstitut Pasteur de la Guadeloupe · GP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent.

methodsWe used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®.

resultsOverall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections.

conclusionsThese results show a different distribution of oncogenic HPVs in Guadeloupe with "31 >  33 > 16" and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.

Indexed as

AdultCervix UteriCoinfectionDNA, ViralFemaleGuadeloupeHuman papillomavirus 16Human papillomavirus 18HumansIncidenceMiddle AgedPapillomavirus InfectionsPapillomavirus VaccinesRetrospective StudiesUterine Cervical DysplasiaUterine Cervical NeoplasmsDNA, ViralHuman Papillomavirus Recombinant Vaccine nonavalentPapillomavirus VaccinesCaribbeanCervical cancerGuadeloupeHuman papilloma virus

Identifiers

PMID33726684
PMCPMC7962384
OpenAlexW3136691698

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.