ArticleBiology letters2021
Short telomeres drive pessimistic judgement bias in zebrafish.
Article in Biology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Balancing consistency and flexibility: exploring trait and state optimism in rats using the cognitive judgement bias test.Frontiers in veterinary science · 2026Article
- A functional framework for a comprehensive study of welfare in fishes.Proceedings. Biological sciences · 2025Review
- Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish.Translational psychiatry · 2025Article
- Cognitive Bias in Adult Zebrafish (Veterinary sciences · 2025Review
- Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle.Frontiers in physiology · 2025Article
- The Universal Optimism of the Self-Evidencing Mind.Entropy (Basel, Switzerland) · 2024Article
- Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.Disease models & mechanisms · 2024Article
- Trait sensitivity to stress and cognitive bias processes in fish: A brief overview.Personality neuroscience · 2024Review
- Unexpected appetitive events promote positive affective state in juvenile European sea bass.Scientific reports · 2023Article
- Article
- Pessimistic cognitive bias is associated with enhanced reproductive investment in female zebrafish.Biology letters · 2022Article
- Looking beyond the Shoal: Fish Welfare as an Individual Attribute.Animals : an open access journal from MDPI · 2022Article
- Causes and consequences of variation in early-life telomere length in a bird metapopulation.Ecology and evolution · 2022Article
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
- A Behavioural Assay to Investigate Judgment Bias in Zebrafish.Bio-protocol · 2022Article
- Review
- Short telomeres drive pessimistic judgement bias in zebrafish.Biology letters · 2021Article
- Research Before Policy: Identifying Gaps in Salmonid Welfare Research That Require Further Study to Inform Evidence-Based Aquaculture Guidelines in Canada.Frontiers in veterinary science · 2021Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judgement bias experimental paradigm to measure subjective evaluations of ambiguous stimuli in zebrafish. This behavioural assay allows classification of individuals in an optimistic-pessimistic dimension (i.e. from individuals that consistently evaluate ambiguous stimuli as negative to others that perceive them as positive). Using this behavioural paradigm we found that telomerase-deficient zebrafish (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.