Evidence map›Paper›PMID 33726538›Full record

ArticleJournal of psychopharmacology (Oxford, England)2021

Association of the

Miriam Sebold, Maria Garbusow, Deniz Cerci, Ke Chen, Christian Sommer, Quentin Jm Huys, Stephan Nebe, Michael Rapp, Ilya M Veer, Ulrich S Zimmermann and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024
    Article
  6. Flexible control of Pavlovian-instrumental transfer based on expected reward value.Journal of experimental psychology. Animal learning and cognition · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Miriam SeboldDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0002-6006-3201
Maria GarbusowDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Deniz CerciKlinik für Forensische Psychiatrie, Universitätsmedizin Rostock, Rostock, Germany.
Ke ChenDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Christian SommerTechnical University of Dresden, Dresden, Germany.
Quentin Jm HuysDivision of Psychiatry, University College London, London, UK.
Stephan NebeDepartment of Economics, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3968-9557
Michael RappDepartment for Social and Preventive Medicine, University of Potsdam, Potsdam, Germany.
Ilya M VeerDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Ulrich S ZimmermannTechnical University of Dresden, Dresden, Germany.
Michael N SmolkaTechnical University of Dresden, Dresden, Germany.ORCID 0000-0001-5398-5569
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Eva FriedelDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Humboldt-Universität zu Berlin · DETechnische Universität Dresden · DEUniversity of Potsdam · DEIsar-Amper-Klinikum München-Ost · DEProstate Cancer Research · GBUniversitätsmedizin Rostock · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian-instrumental interactions. The A118G polymorphism of the

methodsUsing a PIT task, we examined three independent samples: young healthy subjects (

resultsIn all three samples, participants with the minor

conclusionThese results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD.

Indexed as

RewardAdolescentAdultAlcoholismCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedMotivationPolymorphism, Single NucleotideReceptors, Opioid, muRecurrenceTransfer, PsychologyOPRM1 protein, humanReceptors, Opioid, muAlcohol dependencedecision makinglearningopioid systemOPRM1 A118G

Identifiers

PMID33726538
PMCPMC8155738
OpenAlexW3138917883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.