Evidence map›Paper›PMID 33725262›Full record

ArticleClinical reviews in allergy & immunology2022

Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals.

Laura Andreoli, Cecilia Nalli, Maria Grazia Lazzaroni, Chiara Carini, Francesca Dall'Ara, Rossella Reggia, Marília Rodrigues, Carolina Benigno, Elena Baldissera, Elena Bartoloni and 53 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical reviews in allergy & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors at 20 institutions in 1 country.

Laura Andreoli *Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy. laura.andreoli@unibs.it.ORCID http://orcid.org/0000-0002-9107-3218
Cecilia Nalli *Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Piazzale Spedali Civili 1, 25123, Brescia, Italy.
Maria Grazia LazzaroniDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Chiara CariniDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Francesca Dall'AraDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Rossella ReggiaDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Marília RodriguesCentro Hospitalar de Leiria (CHL), Hospital de Santo André (HSA), R. de Santo André, 2410-197, Leiria, Portugal.
Carolina BenignoRheumatology Research Unit, Department of Clinical Medicine and Surgery, University Federico II of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.
Elena BaldisseraUnit of Medicine and Clinical Immunology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Elena BartoloniDepartment of Medicine, Rheumatology Unit, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Fabio BastaUnit of Allergology, Clinical Immunology and Rheumatology, University Campus Biomedico Rome, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
Francesca BellisaiRheumatology Unit, Policlinico Le Scotte and University of Siena, Via Mario Bracci-Loc.Le Scotte, 53100, Siena, Italy.
Alessandra BortoluzziRheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy.
Corrado CampochiaroUnit of Medicine and Clinical Immunology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Francesco Paolo CantatoreRheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Rione Biccari, 71122, Foggia, Italy.
Roberto CaporaliDepartment of Rheumatology, ASST Istituto Gaetano Pini & CTO, Piazza Cardinale Andrea Ferrari, 1, 20122, Milan, Italy.
Angela CeribelliDivision of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via Manzoni 56Rozzano Milano, 20089, Milan, Italy.
Cecilia B ChighizolaUnit of Rheumatology, Istituto Auxologico Italiano, Via Mosè Bianchi, 90, 20149, Milan, Italy.
Paola ConigliaroRheumatology, Allergy and Clinical Immunology, University of Rome Tor Vergata, Via Oxford 81, 00133, Rome, Italy.
Addolorata CorradoRheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Rione Biccari, 71122, Foggia, Italy.
Maurizio CutoloResearch Laboratory and Division of Rheumatology, Postgraduate School of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV 16, 16132, Genova, Italy.
Salvatore D'AngeloRheumatology Institute of Lucania (IReL) - Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna Delle Grazie Hospital of Matera, Via Potito Petrone 1, 85100, Potenza, Italy.
Elena De StefaniRheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy.
Andrea DoriaRheumatology Unit, Department of Medicine-DIMED, University of Padua, Via Nicolò Giustiniani, 2, 35128, Padua, Italy.
Maria FavaroRheumatology Unit, Department of Medicine-DIMED, University of Padua, Via Nicolò Giustiniani, 2, 35128, Padua, Italy.
Colomba FischettiClinica Medica, Università Politecnica Delle Marche, Via Tronto, 10/a, 60126, Ancona, Italy.
Rosario FotiRheumatology Unit, A.O.U. Policlinico Vittorio Emanuele, Via S. Sofia 78, 95123, Catania, Italy.
Armando GabrielliClinica Medica, Università Politecnica Delle Marche, Via Tronto, 10/a, 60126, Ancona, Italy.
Elena GeneraliDivision of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via Manzoni 56Rozzano Milano, 20089, Milan, Italy.
Roberto GerliDepartment of Medicine, Rheumatology Unit, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Maria GerosaDepartment of Rheumatology, ASST Istituto Gaetano Pini & CTO, Piazza Cardinale Andrea Ferrari, 1, 20122, Milan, Italy.
Maddalena LarosaRheumatology Unit, Department of Medicine-DIMED, University of Padua, Via Nicolò Giustiniani, 2, 35128, Padua, Italy.
Armin MaierRheumatology Outpatient Clinic, Internal Medicine Department, Hospital of Bolzano, Via Lorenz Böhler 5, 39100, Bolzano, Italy.
Nazzarena MalavoltaRheumatology Unit, Internal Medicine, Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria Di Bologna, Via Pietro Albertoni 15, 40138, Bologna, Italy.
Marianna MeroniHumanitas Gavazzeni, ASL 5 Spezzino, BergamoLa Spezia, Italy.
Pier Luigi MeroniUnit of Rheumatology, Istituto Auxologico Italiano, Via Mosè Bianchi, 90, 20149, Milan, Italy.
Carlomaurizio MontecuccoDivision of Rheumatology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.
Marta MoscaRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.
Melissa PadovanRheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy.
Giuseppe PaolazziDepartment of Rheumatology, S. Chiara Hospital, Largo Medaglie D'oro 9, 38122, Trento, Italy.
Giulia PazzolaRheumatology Unit, Azienda USL-IRCCS of Reggio Emilia, University of Modena and Reggio Emilia, Viale Risorgimento, 80, 42123, Reggio-Emilia, Italy.
Susanna PeccatoriDepartment of Rheumatology, S. Chiara Hospital, Largo Medaglie D'oro 9, 38122, Trento, Italy.
Roberto PerriconeRheumatology, Allergy and Clinical Immunology, University of Rome Tor Vergata, Via Oxford 81, 00133, Rome, Italy.
Giorgio PettitiUnit of Rheumatology, S.Croce E Carle Hospital, Via Michele Coppino, 26, 12100, Cuneo, Italy.
Valentina PicernoRheumatology Institute of Lucania (IReL) - Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna Delle Grazie Hospital of Matera, Via Potito Petrone 1, 85100, Potenza, Italy.
Immacolata PreveteRheumatology Unit, San Camillo Hospital, Circonvallazione Gianicolense, 87, 00152, Rome, Italy.
Véronique RamoniDivision of Rheumatology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.
Nicoletta RomeoUnit of Rheumatology, S.Croce E Carle Hospital, Via Michele Coppino, 26, 12100, Cuneo, Italy.
Amelia RuffattiRheumatology Unit, Department of Medicine-DIMED, University of Padua, Via Nicolò Giustiniani, 2, 35128, Padua, Italy.
Carlo SalvaraniRheumatology Unit, Azienda USL-IRCCS of Reggio Emilia, University of Modena and Reggio Emilia, Viale Risorgimento, 80, 42123, Reggio-Emilia, Italy.
Gian Domenico SebastianiRheumatology Unit, San Camillo Hospital, Circonvallazione Gianicolense, 87, 00152, Rome, Italy.
Carlo SelmiDivision of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via Manzoni 56Rozzano Milano, 20089, Milan, Italy.
Francesca SeraleUnit of Rheumatology, S.Croce E Carle Hospital, Via Michele Coppino, 26, 12100, Cuneo, Italy.
Luigi SinigagliaDepartment of Rheumatology, ASST Istituto Gaetano Pini & CTO, Piazza Cardinale Andrea Ferrari, 1, 20122, Milan, Italy.
Chiara TaniRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.
Marica TrevisaniRheumatology Unit, Internal Medicine, Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria Di Bologna, Via Pietro Albertoni 15, 40138, Bologna, Italy.
Marta VadaccaUnit of Allergology, Clinical Immunology and Rheumatology, University Campus Biomedico Rome, Via Álvaro del Portillo, 21, 00128, Rome, Italy.
Eleonora ValentiniDepartment of Medicine, Rheumatology Unit, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Guido ValesiniRheumatology Unit, Department of Internal Medicine and Medical Specialties, La Sapienza University, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Elisa VisalliRheumatology Unit, A.O.U. Policlinico Vittorio Emanuele, Via S. Sofia 78, 95123, Catania, Italy.
Ester VivaldelliRheumatology Outpatient Clinic, Internal Medicine Department, Hospital of Bolzano, Via Lorenz Böhler 5, 39100, Bolzano, Italy.
Lucia ZulianiClinica Medica, Università Politecnica Delle Marche, Via Tronto, 10/a, 60126, Ancona, Italy.
Angela TincaniDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Padua · ITIRCCS Humanitas Research Hospital · ITMarche Polytechnic University · ITUniversity of Brescia · ITUniversity of Ferrara · ITUniversity of Perugia · ITAzienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITIRCCS Istituto Auxologico Italiano · ITIRCCS San Camillo Hospital · ITOspedale di Bolzano · ITOspedale Madonna Delle Grazie · ITOspedale Santa Chiara · ITUniversità Campus Bio-Medico · ITUniversity of Foggia · ITUniversity of Milan · ITUniversity of Modena and Reggio Emilia · ITUniversity of Pavia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concern about the offspring's health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children. By surveying 398 patients who received their diagnosis of RD during childbearing age (before the age of 45), information about the offspring were obtained from 230 women who declared to have had children. A total of 148 (64.3%) patients were affected by connective tissue diseases (CTD) and 82 (35.7%) by chronic arthritis. Data on 299 children (156 males, 52.1%; mean age at the time of interview 17.1 ± 9.7 years) were collected. Twelve children (4.0%), who were born to patients with CTD in 75% of the cases, were affected by AD (8 cases of celiac disease). Eleven children had a certified diagnosis of ND (3.6%; 6 cases of learning disabilities); 9 of them were born to mothers with CTD (5 after maternal diagnosis). No association was found between ND and prenatal exposure to either maternal autoantibodies or anti-rheumatic drugs. Absolute numbers of offspring affected by AD and ND were low in a multicentre cohort of Italian women with RD. This information can be helpful for the counselling about reproductive issues, as the health outcomes of the offspring might not be an issue which discourage women with RD from having children.

Indexed as

Antirheumatic AgentsAutoimmune DiseasesRheumatic DiseasesAutoantibodiesChildCohort StudiesFemaleHumansMalePregnancyAntirheumatic AgentsAutoantibodiesCounsellingNeurodevelopmental disordersOffspringReproductive issuesRheumatic diseases

Identifiers

PMID33725262
PMCPMC8994724
OpenAlexW3136014755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.