Evidence map›Paper›PMID 33725256›Full record

ArticleBulletin of experimental biology and medicine2021

Secretory Activity of Mesenchymal Stromal Cells with Different Degree of Commitment under Conditions of Simulated Microgravity.

I V Zhivodernikov, A Yu Ratushnyy, L B Buravkova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

I V ZhivodernikovState Scientific Center of the Russian Federation - Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
A Yu RatushnyyState Scientific Center of the Russian Federation - Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
L B BuravkovaState Scientific Center of the Russian Federation - Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. buravkova@imbp.ru.
Institute of Biomedical Problems · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microgravity negatively affects the bone tissue which manifested in a decrease in mineral density of the bones during long-term space flights. Impairments of bone homeostasis are determined among other things by changes in secretory activity of heterogeneous populations of low-committed precursors, such as mesenchymal stromal cells (MSC) and osteoblasts. We studied the effect of microgravity modeling during 10 days on paracrine activity of osteogenically committed and intact MSC. Cell response to simulated microgravity depended on the degree of commitment. The response of osteogenically committed MSC was less pronounced and manifested in increased production of sclerostin. In intact MSC, an increase in IL-8 and VEGF secretion and a decrease in osteoprotegerin level were detected. These changes can underlie the shift of bone homeostasis towards bone resorption.

Indexed as

Cell DifferentiationCells, CulturedHumansMesenchymal Stem CellsOsteoblastsOsteogenesisWeightlessnessWeightlessness Simulationmesenchymal stromal cells (MSC)osteogenesisparacrine activitysimulated microgravity effects

Identifiers

PMID33725256
OpenAlexW3137352694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.