Evidence map›Paper›PMID 33725255›Full record

ArticleBulletin of experimental biology and medicine2021

Activation of TLR4 of Mesenchymal Stem Cells Enhances the Regenerative Properties of Their Secretomes.

A L Rusanov, Yu K Biryukova, O O Shoshina, E D Luzgina, N G Luzgina

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A L RusanovV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. alexander.l.rusanov@gmail.com.
Yu K BiryukovaPerspectiva Research-and-Production Company, Novosibirsk, Russia.
O O ShoshinaPerspectiva Research-and-Production Company, Novosibirsk, Russia.
E D LuzginaV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
N G LuzginaV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Institute of Biomedical Chemistry · RUScientific Research Institute of Experimental and Clinical Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSC), like macrophages, can be polarized in vitro. In particular, activation of type 4 Toll-like receptor in MSC leads to the appearance of the so-called "proinflammatory" MSC phenotype (MSC1). We showed that secretome (conditioned media) of MSC1 can affect the wound healing processes: promote healing and modulate exudative inflammation and subsequent fibroplastic processes in the damaged area. These effects of secretomes of polarized MSC were superior to those of intact MSC.

Indexed as

AnimalsCulture Media, ConditionedInterleukin-6Interleukin-8MacrophagesMaleMesenchymal Stem CellsRatsRats, WistarToll-Like Receptor 4Wound HealingCulture Media, ConditionedInterleukin-6Interleukin-8Toll-Like Receptor 4cell secretomesinflammatory infiltratesphenotype of mesenchymal stem cells“proinflammatory” cell phenotypewound healing process

Identifiers

PMID33725255
OpenAlexW3139472514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.