ArticleEuropean radiology2021
Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- The clinical relevance of chest computed tomography imaging in pulmonary hypertension associated with lung diseases.Current opinion in pulmonary medicine · 2026Review
- CT-based lung ventilation metrics: reference ranges and pulmonary function test correlations in healthy individuals.European radiology · 2026Article
- CT-derived quantitative imaging biomarkers for hypoxemia risk in repeated lung resection: a retrospective study.BMC medical imaging · 2026Article
- Assessment of CT quantitative characteristics derived from CT in connective tissue disease-associated interstitial lung disease.Journal of thoracic disease · 2026Article
- Investigating the impact of key algorithm parameters and patient-specific factors on the accuracy of CT ventilation imaging.Journal of applied clinical medical physics · 2026Article
- Comparison of Signal- and Volume-Based Ventilation-Weighted Assessment Using 3D FLORET UTE MRI in Patients With Various Pulmonary Disease.Magnetic resonance in medicine · 2026Article
- Association of dual-energy CT-derived quantitative parameters with hydroxyproline levels and pulmonary function in nonspecific interstitial pneumonia.Frontiers in immunology · 2026Article
- Extent of alveolar collapse in expiratory CT as a prognostic marker in idiopathic pulmonary fibrosis.PloS one · 2026Article
- Imaging technologies in experimental pulmonary fibrosis research: essential tool for enhanced translational relevance.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Quantitative lung CT indicators have good predictive ability for hypoxemia during one-lung ventilation in radical resection for lung cancer.Journal of anesthesia · 2025Article
- More accessible functional lung imaging: non-contrast CT-ventilation demonstrates strong association and agreement with PET-ventilation.Respiratory research · 2025Article
- Review
- Lung functional imaging.Breathe (Sheffield, England) · 2023Article
- Thoracic Diseases: Technique and Applications of Dual-Energy CT.Diagnostics (Basel, Switzerland) · 2023Review
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- An analysis of the regional heterogeneity in tissue elasticity in lung cancer patients with COPD.Frontiers in medicine · 2023Article
- Performance of virtual non-contrast images generated on clinical photon-counting detector CT for emphysema quantification: proof of concept.The British journal of radiology · 2022Article
- Quantification of Cancer-Developing Idiopathic Pulmonary Fibrosis Using Whole-Lung Texture Analysis of HRCT Images.Cancers · 2021Article
- Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion ofInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe individual course of disease in idiopathic pulmonary fibrosis (IPF) is highly variable. Assessment of disease activity and prospective estimation of disease progression might have the potential to improve therapy management and indicate the onset of treatment at an earlier stage. The aim of this study was to evaluate whether regional ventilation, lung perfusion, and late enhancement can serve as early imaging markers for disease progression in patients with IPF.
methodsIn this retrospective study, contrast-enhanced dual-energy CT scans of 32 patients in inspiration and delayed expiration were performed at two time points with a mean interval of 15.4 months. The pulmonary blood volume (PBV) images obtained in the arterial and delayed perfusion phase served as a surrogate for arterial lung perfusion and parenchymal late enhancement. The virtual non-contrast (VNC) images in inspiration and expiration were non-linearly registered to provide regional ventilation images. Image-derived parameters were correlated with longitudinal changes of lung function (FVC%, DLCO%), mean lung density in CT, and CT-derived lung volume.
resultsRegional ventilation and late enhancement at baseline preceded future change in lung volume (R - 0.474, p 0.006/R - 0.422, p 0.016, respectively) and mean lung density (R - 0.469, p 0.007/R - 0.402, p 0.022, respectively). Regional ventilation also correlated with a future change in FVC% (R - 0.398, p 0.024).
conclusionCT-derived functional parameters of regional ventilation and parenchymal late enhancement are potential early imaging markers for idiopathic pulmonary fibrosis progression. KEY POINTS: • Functional CT parameters at baseline (regional ventilation and late enhancement) correlate with future structural changes of the lung as measured with loss of lung volume and increase in lung density in serial CT scans of patients with idiopathic pulmonary fibrosis. • Functional CT parameter measurements in high-attenuation areas (- 600 to - 250 HU) are significantly different from normal-attenuation areas (- 950 to - 600 HU) of the lung. • Mean regional ventilation in functional CT correlates with a future change in forced vital capacity (FVC) in pulmonary function tests.
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