Evidence map›Paper›PMID 33725152›Full record

ArticleCalcified tissue international2021

Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation.

Mahéva Vallet, Antonia Sophocleous, Anna E Törnqvist, Asim Azfer, Rob Van't Hof, Omar Me Albagha, Stuart H Ralston

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases.Frontiers in cell and developmental biology · 2022
    Review
  3. Article
  4. Update on the pathogenesis and genetics of Paget's disease of bone.Frontiers in cell and developmental biology · 2022
    Review
  5. Genetic Determinants of Paget's Disease of Bone.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Mahéva ValletInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Antonia SophocleousInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Anna E TörnqvistCentre for Bone and Arthritis Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Asim AzferInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Rob Van't HofInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, England.
Omar Me AlbaghaInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Stuart H RalstonInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. stuart.ralston@ed.ac.uk.ORCID 0000-0002-2804-7586
Institute of Genetics and Cancer · GBEuropean University Cyprus · CYHamad bin Khalifa University · QAUniversity of Gothenburg · SEUniversity of Liverpool · GB

Funding

Arthritis Research UK 19799H2020 European Research Council 787270Horizon 2020 Framework Programme 311723Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

Common genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget's disease of bone (PDB) but the mechanisms by which they do so are unknown. Here, we analysed the skeletal phenotype of female mice with targeted inactivation of the mouse Rin3 gene (Rin3

Indexed as

Bone ResorptionOsteitis DeformansAnimalsBone DensityCancellous BoneFemaleFemurMiceOsteoclastsOsteogenesisGeneticOsteoclastPaget’s diseaseRIN3

Identifiers

PMID33725152
PMCPMC8225545
OpenAlexW3136649925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.