ArticlePLoS neglected tropical diseases2021
Towards the elimination of leprosy in Yunnan, China: A time-series analysis of surveillance data.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability.International journal of environmental research and public health · 2022Pooled it
- Human resource challenges in leprosy control: A cross-sectional study in southwest border area of China.PLoS neglected tropical diseases · 2026Article
- The prevalence of anxiety, depression and the mediating role in leprosy patients: a nationally representative cross-sectional study.Scientific reports · 2025Article
- Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045.Infectious medicine · 2025Article
- Preliminary evaluation of a neurological clinical pathway for the early detection of leprosy in low-endemic settings: A single-center exploratory study.Scientific reports · 2025Article
- Socioeconomic determinants of the leprosy risk in Yunnan Province, China: a county-level spatiotemporal study.Frontiers in public health · 2025Article
- High-risk spatiotemporal patterns of leprosy in the southeastern region of Yunnan province from 2010 to 2022: an analysis at the township level.BMC public health · 2024Article
- Spatiotemporal pattern of leprosy in southwest China from 2010 to 2020: an ecological study.BMC public health · 2024Observational
- The burden of physical disability among patients with newly detected leprosy in Yunnan, China, 1990-2020: A population-based, cross-sectional survey.PLoS neglected tropical diseases · 2022Article
- Oscillatory properties of class C notifiable infectious diseases in China from 2009 to 2021.Frontiers in public health · 2022Article
- Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.PLoS neglected tropical diseases · 2021Observational
- The state of the leprosy epidemic in Yunnan, China 2011-2020: A spatial and spatiotemporal analysis, highlighting areas for intervention.PLoS neglected tropical diseases · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study reviews the progress of leprosy elimination in Yunnan, China, over the past 30 years and identifies the challenges for the next stage of the program. METHODOLOGY/PRINCIPAL
findingsData were collected from the Leprosy Management Information System in China (LEPMIS). The progress made in the elimination of leprosy between 1990 and 2019 was measured. We defined two time periods, time period 1 (1990-2003) and time period 2 (2004-2019), because multidrug therapy (MDT) was launched for the treatment of leprosy in 1990 and a special fund from the central government was established for leprosy in 2004. During the past 30 years, the number of newly detected leprosy patients in Yunnan has steadily declined. In total, 703 newly detected leprosy patients were reported in 1990, and 353 and 136 cases were reported at the end of 2003 and 2019, respectively. At the end of 1990, 90.7% (117/129) of counties in Yunnan Province were identified as leprosy-endemic counties (>1 case per 100,000 population). By the end of 2003 and 2019, 39.3% (46/117) and 85.5% (100/117) of the leprosy-endemic counties, respectively, had dropped below the elimination threshold. The main challenges are the remaining leprosy-endemic counties, the high rate of cases with a contact history, insufficient early detection, and leprosy cases resulting in physical disability. CONCLUSIONS/SIGNIFICANCE: A multifaceted strategy for leprosy elimination in Yunnan Province has been successfully implemented, and remarkable progress has been made in the elimination of leprosy in this area. The priorities for leprosy elimination in the next stage are securing sustainable support and investment from the government, establishing an effective surveillance system, ensuring prompt early detection, providing treatment with MDT, preventing transmission of M. leprae, preventing disability, providing health education, and preventing recurrence of the epidemic situation of leprosy.
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