SynthesisThe American journal of tropical medicine and hygiene2021
Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis.
Synthesis in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Echocardiographic assessment of cardiac function in children with severe malaria attending two tertiary hospitals in southeast Nigeria.European journal of pediatrics · 2026Observational
- Global epidemiology of myocarditis: disparities in age, sex and geography.Nature reviews. Cardiology · 2026Review
- A Case of Plasmodium vivax-Induced Stress Cardiomyopathy Managed With Extracorporeal Membrane Oxygenation.Cureus · 2025Article
- Acute Myocarditis in the Setting of Plasmodium vivax Malaria: A Case Report and Review of the Literature.The American journal of tropical medicine and hygiene · 2025Review
- Anesthetic approach to pregnant patients with malaria: a narrative review of the literature.Journal of anesthesia, analgesia and critical care · 2024Review
- Infectious factors in myocarditis: a comprehensive review of common and rare pathogens.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Mechanism of Immune Evasion in Mosquito-Borne Diseases.Pathogens (Basel, Switzerland) · 2023Review
- Left ventricular function by strain in uncomplicated malaria: a prospective study from the Brazilian Amazon.The international journal of cardiovascular imaging · 2023Article
- Epidemiological shifts: the emergence of malaria in America.Proceedings (Baylor University. Medical Center) · 2023Review
- Article
- Case of myocarditis secondary to severeBMJ case reports · 2022Article
- Acute Kidney Injury Interacts With Coma, Acidosis, and Impaired Perfusion to Significantly Increase Risk of Death in Children With Severe Malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Role of Endomyocardial Biopsy in Diagnostics of Myocarditis.Diagnostics (Basel, Switzerland) · 2022Review
- Heart failure associated with imported malaria: a nationwide Danish cohort study.ESC heart failure · 2021Article
- Cardiopulmonary alterations by ultrasound in a patient with uncomplicated mixed malaria infection: a case report from the Amazon Basin.Malaria journal · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that malaria may affect the cardiovascular system. The aim of this systematic review and meta-analysis was to determine the prevalence of cardiovascular complications in symptomatic malaria patients. We searched databases such as Pubmed, Embase, Cochrane, and Web of Science (January 1950-April 2020) for studies reporting on cardiovascular complications in adults and children with malaria. Cardiovascular complications were defined as abnormalities in electrocardiogram (ECG), cardiac biomarkers, and echocardiography on admission or during outpatient examination. Studies of patients with known heart disease or cardiovascular evaluation performed after the start of intravenous antimalarial medication were excluded. The study was registered in International Prospective Register of Systematic Reviews (PROSPERO) (No.: CRD42020167672). The literature search yielded 1,243 studies, and a total of 43 studies with symptomatic malaria patients were included. Clinical studies (n = 12 adults; n = 5 children) comprised 3,117 patients, of which a majority had Plasmodium falciparum (n = 15) and were diagnosed with severe malaria (n = 13). In random-effects models of adults, the pooled prevalence estimate for any cardiovascular complication was 7% (95% CI: 5-9). No meta-analysis was conducted in children, but the range of abnormal ECG was 0-8%, cardiac biomarkers 0-57%, and echocardiography 4-9%. We analyzed 33 cases (n = 10 postmortem), in which the most common cardiovascular pathologies were myocarditis and acute coronary syndrome. All histopathological studies found evidence of parasitized red blood cells in the myocardium. Cardiovascular complications are not uncommon in symptomatic adults and children with malaria. Additional studies investigating malaria and cardiovascular disease are encouraged.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.