Evidence map›Paper›PMID 33724898›Full record

Trial reportThe International journal of clinical and experimental hypnosis

Efficacy of a Self-Hypnotic Relaxation App on Pain and Anxiety in a Randomized Clinical Trial: Results and Considerations on the Design of Active and Control Apps.

Elvira V Lang, William Jackson, Paul Senn, Donavon Khosrow K Aroni, Matthew D Finkelman, Thomas A Corino, Graham Conway, Ronald J Kulich

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The International journal of clinical and experimental hypnosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05194449 (Nonpharmacologic Reduction of Periprocedural Pain, Anxiety, and Prescription Drug Use Phase II), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05194449 nawithdrawnnot on this map

Nonpharmacologic Reduction of Periprocedural Pain, Anxiety, and Prescription Drug Use Phase II

TypeinterventionalSponsorHypnalgesics, LLCRan2022 to 2024Enrolled0ConditionsDental Anxiety, Dental Pain, Root WorkArmsComfort Talk® App, Placebo App
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elvira V LangHypnalgesics, LLC, Brookline, Massachusetts, USA.ORCID 0000-0002-4348-5138
William JacksonCraniofacial Pain Center, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
Paul SennHypnalgesics, LLC, Brookline, Massachusetts, USA.
Donavon Khosrow K AroniCraniofacial Pain Center, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
Matthew D FinkelmanDepartment of Public Health and Community Service, TuftsUniversity School of Dental Medicine, Boston, Massachusetts, USA.
Thomas A CorinoHypnalgesics, LLC, Brookline, Massachusetts, USA.
Graham ConwayHypnalgesics, LLC, Brookline, Massachusetts, USA.
Ronald J KulichCraniofacial Pain Center, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.

Funding

Nonpharmacologic reduction of periprocedural pain, anxiety, and prescription drug useR43AT009517 · NCCIH · HYPNALGESICS, LLC · PI LANG-ANDERSON, ELVIRA VALENTINA · 2017 to 2017
$150k
NCCIH NIH HHS R43 AT009517
6 · The paper itself

Abstract

Despite an explosion of mobile app offerings for management of pain and anxiety, the evidence for effectiveness is scarce. Placebo-controlled trials are the most desirable but designing inactive placebo apps can be challenging. For a prospective randomized clinical trial with 72 patients in a craniofacial pain center, we created an app with self-hypnotic relaxation (SHR) for use with iOS and Android systems. A placebo background audio (BA) app was built with the same look and functionality. Both iOS and Android SHR apps alone and in comparison to the BA group significantly reduced pain and anxiety during the waiting-room time. The Android BA app significantly reduced anxiety but not pain. The iOS BA app affected neither pain nor anxiety, functioning as an ideal placebo. Usage analysis revealed that different default approaches of the iOS and Android devices accounted for the difference in results.

Indexed as

HypnosisMobile ApplicationsAnxietyHumansHypnotics and SedativesPainProspective StudiesHypnotics and Sedatives

Identifiers

PMID33724898
PMCPMC9976960

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.