Evidence map›Paper›PMID 33724814›Full record

ReviewChemical reviews2021

Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.

Phillip E Klebba, Salete M C Newton, David A Six, Ashish Kumar, Taihao Yang, Brittany L Nairn, Colton Munger, Somnath Chakravorty

Open access · greenAbstract readReview
In one paragraph

Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 137 citations in OpenAlex.

  1. Review
  2. Article
  3. Influence of iron uptake systems on cefiderocol activity inAntimicrobial agents and chemotherapy · 2026
    Article
  4. Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Longitudinal genomic insights into resistance and virulence dynamics of Klebsiella pneumoniae clinical isolates from Pakistan.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  9. TheInternational journal of molecular sciences · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
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  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Phillip E KlebbaDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, United States.ORCID 0000-0002-6979-3083
Salete M C NewtonDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, United States.
David A SixVenatorx Pharmaceuticals, Inc., 30 Spring Mill Drive, Malvern, Pennsylvania 19355, United States.ORCID 0000-0002-9013-1711
Ashish KumarDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, United States.
Taihao YangDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, United States.
Brittany L NairnDepartment of Biological Sciences, Bethel University, 3900 Bethel Drive, St. Paul, Minnesota 55112, United States.
Colton MungerDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, United States.
Somnath ChakravortyJacobs School of Medicine and Biomedical Sciences, SUNY Buffalo, Buffalo, New York 14203, United States.
Kansas State University · USBethel University · USJacobs Institute · USVenatoRx Pharmaceuticals (United States) · US

Funding

Development of Therapeutic Products for Antibiotic Resistant Bacteria75N93020C00016 · NIAID · VENATORX PHARMACEUTICALS, INC. · PI PEVEAR, DANIEL · 2020 to 2025
$25.1M
High-throughput fluorescence screening for inhibitors of TonB-dependent iron transportR21AI115187 · NIAID · KANSAS STATE UNIVERSITY · PI KLEBBA, PHILLIP E · 2015 to 2016
$388k
NIAID NIH HHS 75N93020C00016NIAID NIH HHS R21 AI115187
6 · The paper itself

Abstract

Iron is an indispensable metabolic cofactor in both pro- and eukaryotes, which engenders a natural competition for the metal between bacterial pathogens and their human or animal hosts. Bacteria secrete siderophores that extract Fe

Indexed as

AnimalsAnti-Bacterial AgentsBacterial ProteinsFerric CompoundsGram-Negative BacteriaHumansIronMembrane ProteinsModels, MolecularSiderophoresAnti-Bacterial AgentsBacterial ProteinsFerric CompoundsIronMembrane ProteinsSiderophorestonB protein, Bacteria

Identifiers

PMID33724814
PMCPMC8687107
OpenAlexW3137122686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.