Evidence map›Paper›PMID 33724785›Full record

ArticleACS nano2021

Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles.

Assaf Zinger, Manuela Sushnitha, Tomoyuki Naoi, Gherardo Baudo, Enrica De Rosa, Jenny Chang, Ennio Tasciotti, Francesca Taraballi

Open access · bronzeAbstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  7. Membrane-modified lipid nanoparticles for RNA delivery.Molecular therapy. Methods & clinical development · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Assaf ZingerCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.ORCID 0000-0001-7894-486X
Manuela SushnithaCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Tomoyuki NaoiCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Gherardo BaudoCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Enrica De RosaCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.ORCID 0000-0002-5832-4740
Jenny ChangHouston Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas 77030, United States.
Ennio TasciottiCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Francesca TaraballiCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.ORCID 0000-0002-4959-1169
Houston Methodist · USMethodist Hospital · US

Funding

Biomimetic nanovesicles to overcome multiple physiological barriers for primary and metastatic triple negative breast cancer therapyR56CA213859 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHANG, JENNY C-N · 2017 to 2017
$300k
Targeting the JAK/STAT3 Pathway in Triple-Negative Breast Cancer Using Biomimetic NanoparticlesF31CA232705 · NCI · RICE UNIVERSITY · PI SUSHNITHA, MANUELA · 2018 to 2020
$121k
NCI NIH HHS F31 CA232705NCI NIH HHS R56 CA213859
6 · The paper itself

Abstract

Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes. Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the

Indexed as

Biomimetic MaterialsExosomesNanoparticlesAnimalsBiomimeticsInflammationLeukocytesbiomimicrycancerinflammationmicrofluidicsnanoparticles

Identifiers

PMID33724785
PMCPMC8155322
OpenAlexW3139469446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.