Evidence map›Paper›PMID 33724732›Full record

ReviewAdvanced biology2021

Nanoparticle-Based Activatable Probes for Bioimaging.

Tiancong Ma, Tian Xia

Abstract readReview
In one paragraph

Review in Advanced biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tiancong MaDivision of Nanomedicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1772, USA.
Tian XiaDivision of Nanomedicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1772, USA.ORCID 0000-0003-0123-1305

Funding

Toxicological Profiling of Engineered Nanomaterials (ENMs) in the MPS (RES)U01ES027237 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS, XIA, TIAN · 2016 to 2020
$2.2M
Linking E-Cigarette Aerosol Characteristics to Mechanisms of Pulmonary ToxicityR01HL139379 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHU, YIFANG · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL139379NIEHS NIH HHS U01 ES027237
6 · The paper itself

Abstract

Molecular imaging can provide functional and molecular information at the cellular or subcellular level in vivo in a noninvasive manner. Activatable nanoprobes that can react to the surrounding physiological environment or biomarkers are appealing agents to improve the efficacy, specificity, and sensitivity of molecular imaging. The physiological parameters, including redox status, pH, presence of enzymes, and hypoxia, can be designed as the stimuli of the activatable probes. However, the success rate of imaging nanoprobes for clinical translation is low. Herein, the recent advances in nanoparticle-based activatable imaging probes are critically reviewed. In addition, the challenges for clinical translation of these nanoprobes are also discussed in this review.

Indexed as

Fluorescent DyesNanoparticlesMolecular ImagingOxidation-ReductionFluorescent Dyesactivatable nanoprobesclinical translationmolecular imagingnanomaterialstheranostics

Identifiers

PMID33724732
PMCPMC7966733

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.