Evidence map›Paper›PMID 33724588›Full record

ArticleHuman brain mapping2021

Sparse deep neural networks on imaging genetics for schizophrenia case-control classification.

Jiayu Chen, Xiang Li, Vince D Calhoun, Jessica A Turner, Theo G M van Erp, Lei Wang, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Erik Jönsson and 6 more

Abstract read
In one paragraph

Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiayu ChenTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology and Emory University), Atlanta, Georgia, USA.ORCID 0000-0001-5059-372X
Xiang LiDepartment of Computer Science, Georgia State University, Atlanta, Georgia, USA.
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology and Emory University), Atlanta, Georgia, USA.
Jessica A TurnerTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology and Emory University), Atlanta, Georgia, USA.
Theo G M van ErpDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, California, USA.
Lei WangDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0003-3870-3388
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo & Oslo University Hospital, Oslo, Norway.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo & Oslo University Hospital, Oslo, Norway.
Lars T WestlyeNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo & Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-8644-956X
Erik JönssonNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo & Oslo University Hospital, Oslo, Norway.
Judith M FordDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Daniel H MathalonDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Fabio MacciardiDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, California, USA.
Daniel S O'LearyDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Jingyu LiuTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology and Emory University), Atlanta, Georgia, USA.ORCID 0000-0002-1724-7523
Shihao JiDepartment of Computer Science, Georgia State University, Atlanta, Georgia, USA.

Funding

FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI BEDRICK, EDWARD J · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia: AD/ADRD supplementR01MH094524 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, TURNER, JESS · 2012 to 2021
$6.3M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
Neurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8M
SchizConnect: Large-Scale Schizophrenia Neuroimaging Data Mediation & FederationU01MH097435 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AMBITE, JOSE LUIS, POTKIN, STEVEN G · 2013 to 2016
$2.0M
Genetic Networks Influencing Gray Matter Changes in Persistent ADHDR01MH106655 · NIMH · THE MIND RESEARCH NETWORK · PI LIU, JINGYU · 2016 to 2019
$1.5M
Schizophrenia Data and Software Tool Federation using BIRN InfrastructureR01MH084803 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, LEI · 2009 to 2011
$933k
NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020062NIGMS NIH HHS P20 GM103472NIGMS NIH HHS P30 GM122734NIH HHS 1R01EB006841NIH HHS 5R01MH094524NIH HHS P20GM103472NIH HHS P30GM122734NIH HHS R01EB005846NIH HHS R01 EB020062NIH HHS R01 MH084803NIH HHS R01MH106655NIH HHS U01 MH097435NIH HHS U24 RR021992NIH HHS U24 RR025736-01NIMH NIH HHS R01 MH084803NIMH NIH HHS R01 MH094524NIMH NIH HHS R01 MH106655NIMH NIH HHS U01 MH097435
6 · The paper itself

Abstract

Deep learning methods hold strong promise for identifying biomarkers for clinical application. However, current approaches for psychiatric classification or prediction do not allow direct interpretation of original features. In the present study, we introduce a sparse deep neural network (DNN) approach to identify sparse and interpretable features for schizophrenia (SZ) case-control classification. An L

Indexed as

Deep LearningNeuroimagingAdultCase-Control StudiesCerebral CortexGray MatterHumansMagnetic Resonance ImagingPolymorphism, Single NucleotideSchizophreniaSupport Vector Machinedeep neural networkgray matter volumeschizophreniasingle nucleotide polymorphismsparse

Identifiers

PMID33724588
PMCPMC8090768

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.