ArticleInternational journal of geriatric psychiatry2021
Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.
Article in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 43 citations in OpenAlex.
- Neuropsychiatric symptoms and dementia development: a 15-year population-based study.The journal of prevention of Alzheimer's disease · 2026Article
- Cognitive heterogeneity in mild cognitive impairment due to Alzheimer's disease pathology.Neural regeneration research · 2026Article
- Validity of the Inventory of Depressive Symptomatology Self-Report (IDS-SR) in Older Adults With Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).BMC psychology · 2026Article
- Understanding the Role of Neuropsychiatric Symptoms in Functional Decline in Alzheimer's Disease.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Relationship between depression, neuropsychiatric symptoms and cognitive profiles of the elderly in India: An assessment using the ICMR-MUDRA toolbox.Global mental health (Cambridge, England) · 2026Article
- Depression and Cognitive Outcomes: Linking the Mayo Clinic Study of Aging and Rochester Epidemiology Project.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Mild Behavioral Impairment: A Population-Based Study.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Uncovering the Role of Neuropsychiatric Symptoms in Cognitive Impairment Progression.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2025Article
- Potential Mechanisms of Influence Between Spiritual Practices and Cognitive Health: A Systematic Review and Conceptual Model.Brain sciences · 2025Review
- Late-life emergence of neuropsychiatric symptoms and risk of cognitive impairment in cognitively unimpaired individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Relationship of Alzheimer's Disease and Related Dementias Blood-Based Biomarkers and Informant-Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia.International journal of geriatric psychiatry · 2025Article
- Association between neuropsychiatric symptoms and neurodegeneration-related plasma biomarkers in older adults with and without clinical dementia in the Democratic Republic of the Congo.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Different association patterns of emotion regulation and heart rate variability in older and younger adults.Brain communications · 2025Article
- Editorial: Neuropsychiatric symptoms and cognitive impairment.Frontiers in neurology · 2025Article
- Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer's disease and related dementias.Journal of the International Neuropsychological Society : JINS · 2025Article
- Neuropsychiatric Symptoms Associated With Frontotemporal Atrophy in Older Adults Without Dementia.International journal of geriatric psychiatry · 2024Article
- Neuropsychiatric Symptom Profile in Alzheimer's Disease and Their Relationship With Functional Decline.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Prediction of cognitive decline in healthy aging based on neuropsychiatric symptoms and PET-biomarkers of Alzheimer's disease.Journal of neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveNeuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain-specific cognitive trajectories.
methodsIn this longitudinal study conducted in the setting of the population-based Mayo Clinic Study of Aging, 5081 community-dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI-Q), and Beck Depression and Anxiety Inventories (BDI-II, BAI). Global and domain-specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z-scores were calculated using linear mixed-effect models.
resultsCognition declined regardless of NPS status over the median follow-up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z-scores for participants with NPS compared to without NPS ranged from -0.018 (95% CI -0.032, -0.004; p = 0.011) for irritability to -0.159 (-0.254, -0.065; p = 0.001) for hallucinations. Associations between NPS and annual decline in global cognition were significant for most NPI-Q-assessed NPS and clinical depression (BDI-II≥13). Participants with NPI-Q-assessed depression, apathy, nighttime behavior, and clinical depression had greater decline in all domain-specific z-scores; presence of delusions and anxiety was associated with more pronounced decline in language, attention and visuospatial skills.
conclusionNPS were associated with a more accelerated cognitive decline. Clinical assessment and potential treatment of NPS is warranted even in a community setting as NPS may impact cognitive decline in nondemented individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.