Evidence map›Paper›PMID 33724186›Full record

ArticleeLife2021

Microglial trogocytosis and the complement system regulate axonal pruning in vivo.

Tony Ky Lim, Edward S Ruthazer

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  6. Microglia and immune signaling as architects of the brain.Frontiers in cellular neuroscience · 2026
    Review
  7. Review
  8. Review
  9. Cross-species protection suggestsInfection and immunity · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. The Arp2/3 complex is required forbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tony Ky LimDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.ORCID 0000-0003-1843-0060
Edward S RuthazerDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.ORCID 0000-0003-0452-3151
Montreal Neurological Institute and Hospital · CA

Funding

CIHR FDN-143238Fonds de Recherche du Québec - Santé 31036
6 · The paper itself

Abstract

Partial phagocytosis-called trogocytosis-of axons by microglia has been documented in ex vivo preparations but has not been directly observed in vivo. The mechanisms that modulate microglial trogocytosis of axons and its function in neural circuit development remain poorly understood. Here, we directly observe axon trogocytosis by microglia in vivo in the developing

Indexed as

Complement ActivationNeuronal PlasticityPhagocytosisAnimalsAxonsCell CommunicationHumansMembrane Cofactor ProteinMicrogliaRetinal Ganglion CellsSynapsesXenopus laevisXenopus ProteinsMembrane Cofactor ProteinXenopus Proteinsaxonbehaviorimmunologyinflammationmicrogliamorphometryneurosciencepruningretinotectalxenopus

Identifiers

PMID33724186
PMCPMC7963485
OpenAlexW3034408479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.