ArticleeLife2021
Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Polycomb Group Proteins inBiology · 2026Review
- Article
- Psc and Su(z)2 safeguard intestinal stem cell identity and prevent chinmo-dependent tumorigenesis.EMBO reports · 2026Article
- A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity.PLoS genetics · 2026Article
- Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation.PLoS biology · 2025Article
- The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration.PLoS genetics · 2025Article
- Enteroendocrine cell differentiation: Implications for human disease.Molecular and cellular endocrinology · 2025Review
- Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications.Biology · 2025Review
- Applications and techniques of single-cell RNA sequencing across diverse species.Briefings in bioinformatics · 2025Review
- Aere perennius: how chromatin fidelity is maintained and lost in disease.NAR molecular medicine · 2025Review
- Measuring Anti-aging Effects inBio-protocol · 2025Article
- Characterization of transcriptomics during aging and genes required for lifespan in Drosophila intestine.Scientific reports · 2025Article
- Article
- Epigenetic clocks and programmatic aging.Ageing research reviews · 2024Review
- Insidious chromatin change with a propensity to exhaust intestinal stem cells during aging.iScience · 2024Article
- Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor.Nature communications · 2024Article
- Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster.Nature communications · 2024Article
- Article
- Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.Nature aging · 2024Article
- Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges.Experimental & molecular medicine · 2024Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single-cell RNA-seq to explore stem-cell-intrinsic changes in the aging
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.