Evidence map›Paper›PMID 33724063›Full record

ArticleRadiology2021

Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids.

Ronald Ouwerkerk, Ahmed Hamimi, Jatin Matta, Khaled Z Abd-Elmoniem, Janet F Eary, Zahraa Abdul Sater, Kong Y Chen, Aaron M Cypess, Ahmed M Gharib

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01399385 narecruitingnot on this map

Magnetic Resonance of Body, Arterial Wall, and Angiography Imaging for Non- Invasive Assessment of Arterial Distensibility, Endothelial Dysfunction and Atherosclerotic Disease Using 1.5T and High Field (3T) MRI: A Technical Development Study of Cardiac and Body Imaging

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2011 to 2030Enrolled4,000ConditionsHealthy, Obesity, Diabetes, Healthy VolunteersArmsMR Imaging Techniques - 1, MR Imaging Techniques - 2, MR Imaging Techniques - 3, MR Imaging Techniques - 4
NCT01568671 nacompletednot on this map

Energy Expenditure Responses to Different Temperatures

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2012 to 2019Enrolled104ConditionsObesity, Normal PhysiologyArmsRoom temperatures
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  13. [Correlation ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Article
  14. Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ronald OuwerkerkFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0003-3882-9757
Ahmed HamimiFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).
Jatin MattaFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0001-6314-9409
Khaled Z Abd-ElmoniemFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0002-1001-1702
Janet F EaryFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0002-8712-8300
Zahraa Abdul SaterFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0003-3069-7788
Kong Y ChenFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0002-0306-1904
Aaron M CypessFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).
Ahmed M GharibFrom the Biomedical and Metabolic Imaging Branch (R.O., A.H., J.M., K.Z.A., A.M.G.) and Diabetes, Endocrinology, and Obesity Branch (Z.A.S., K.Y.C., A.M.C.), National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr, Bldg 10-CRC, Room 3-5340, Bethesda, MD 20892-1263; and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).ORCID 0000-0002-2476-481X
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Advanced Non Invasive Vascular Imaging MethodsZIADK075083 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GHARIB, AHMED · 2013 to 2025
$34.7M
Development of obesity and metabolic clinical research programsZIADK071014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHEN, KONG · 2009 to 2025
$12.3M
Physiological Responses to Activation of Human Brown Adipose TissueZIADK075116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$6.1M
Role of BK-Beta 1 in flow-dependent K+ secretion in the CNTR01DK071014 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SANSOM, STEVEN · 2007 to 2015
$2.7M
Genetic Environmental Relationship Between Bone, Obesity and Leptin in MiceR01DK075112 · NIDDK · WASHINGTON UNIVERSITY · PI CHEVERUD, JAMES M · 2006 to 2010
$1.5M
HTS for Detection of deltaF508 CFTR at the Cell SurfaceR01DK071013 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RIORDAN, JOHN R · 2005 to 2007
$747k
NIDDK NIH HHS R01 DK071013NIDDK NIH HHS R01 DK071014NIDDK NIH HHS R01 DK075112
6 · The paper itself

Abstract

Background Activation of brown adipose tissue (BAT) in rodents increases lipolysis in white adipose tissue (WAT) and improves glucose tolerance. Adult humans can have metabolically active BAT. Implications for diabetes and obesity in humans require a better characterization of BAT in humans. Purpose To study fat depots with localized proton MR spectroscopy relaxometry and to identify differences between WAT and fluorine 18 fluorodeoxyglucose (FDG) PET/CT proven cold-activated BAT in humans. Materials and Methods Participants were consecutively enrolled in this prospective study (ClinicalTrials.gov identifiers: NCT01568671 and NCT01399385) from August 2016 to May 2019. Supraclavicular potential BAT regions were localized with MRI. Proton densities, T1, and T2 were measured with localized MR spectroscopy in potential BAT and in subcutaneous WAT. FDG PET/CT after cold stimulation was used to retrospectively identify active supraclavicular BAT or supraclavicular quiescent adipose tissue (QAT) regions. MR spectroscopy results from BAT and WAT were compared with grouped and paired tests. Results Of 21 healthy participants (mean age, 36 years ± 16 [standard deviation]; 13 men) FDG PET/CT showed active BAT in 24 MR spectroscopy-targeted regions in 16 participants (eight men). Four men had QAT. The T2 for methylene protons was shorter in BAT (mean, 69 msec ± 6, 24 regions) than in WAT (mean, 83 msec ± 3, 18 regions,

Indexed as

Proton Magnetic Resonance SpectroscopyAdipose Tissue, BrownAdipose Tissue, WhiteAdultAgedFatty Acids, UnsaturatedFemaleFluorodeoxyglucose F18Healthy VolunteersHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyProspective StudiesRadiopharmaceuticalsSensitivity and SpecificityFatty Acids, UnsaturatedFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID33724063
PMCPMC8108561
OpenAlexW3137199932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.