Evidence map›Paper›PMID 33724060›Full record

ArticleEpilepsy currents2021

Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits.

Pierre-Pascal Lenck-Santini

Abstract read
In one paragraph

Article in Epilepsy currents, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Pierre-Pascal Lenck-Santini56180Aix-Marseille University, INSERM, INMED, Marseille, France.ORCID https://orcid.org/0000-0001-9925-9220

Funding

Physiological mechanisms responsible for cognitive impairments in Dravet SyndromeR01NS076763 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LENCK-SANTINI, PIERRE PASCAL · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS076763
6 · The paper itself

Abstract

The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical patterns observed in the electroencephalogram and cognitive deficits. Restoring the dynamic coordination of epileptic networks could therefore both improve seizures and cognitive outcomes.

Indexed as

attractor dynamicscognitive comorbiditiesepileptic encephalopathiesGABAergic inhibitionoscillationsrhythmopathiestemporal lobe epilepsy

Identifiers

PMID33724060
PMCPMC8609592

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.