ReviewChemical reviews2021
Chemical Aspects of Human and Environmental Overload with Fluorine.
Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed.
- An overview of fluoride stress: physiological and biochemical responses of plants.Plant signaling & behavior · 2026Review
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Speciation-Controlled C-F Bond Functionalization Enabled by Zwitterionic Pnictinidenes.Angewandte Chemie (International ed. in English) · 2026Article
- Structural Preferences and ADMET Regulation of Fluorinated Small-Molecule Drugs.ACS medicinal chemistry letters · 2026Article
- Article
- Trifluoromethylation-Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids.ChemistryOpen · 2026Review
- Selective Detection of Fe(III) and Al(III) Using an Azo-Functionalized Rhodamine B Chemosensor: Expansion to F- Ion Detection by Al(III)-Probe Complex.Chemistry, an Asian journal · 2026Article
- Second-Generation of Deuterium-Substituted Glutamate Uptake Enhancers Exhibit Superior Drug-Like Properties in Preclinical Evaluation.ACS central science · 2026Article
- Efficient One-Pot Functionalization of Pyrroles via Dearomative Chlorination-Thiocyanation Strategy.International journal of molecular sciences · 2026Article
- The hidden fluorine: a critical review of analytical methods for unmasking PFAS and closing fluorine mass balance in environmental samples.Analytical and bioanalytical chemistry · 2026Review
- Fluorinated Amphiphilic Dendrimer to Improve PET Imaging of Cancer.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Boron-10 carriers and their applications in boron neutron capture therapy.Precision radiation oncology · 2026Review
- Design, Synthesis, and Biological Evaluation of Tetrahydroindazole-Based Sulfonamides as Potential Multi-Target Anti-Inflammatory Agents.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Theoretical Investigation on the Mechanism of NiJACS Au · 2026Article
- A hydrolase from Serratia liquefaciens IMD717 with esterase, dehalogenase and N-deformylase activities.Applied microbiology and biotechnology · 2026Article
- Nickel-Catalyzed Aminocarbonylation of Aryl Trifluoromethoxides.Organic letters · 2026Article
- Benchmark Approach to Unravel Fluoride Toxicity: Liver and Kidney Disruptions in Subacutely Exposed Rats.Journal of xenobiotics · 2026Article
- Fluoride Induces Spermatogonial Apoptosis via IP3R-MCU-Mediated Mitochondrial Calcium Overload.Biological trace element research · 2026Article
- Self-Healing Starch-Based Ionogels with Hydroneutral Dipole-Dipole Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Deciphering Environmental Health Factors Behind Unknown Etiology of Chronic Kidney Disease in South Asia: Plans for Epidemiologic Study.medRxiv : the preprint server for health sciences · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last 100-120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive development of the fluorochemical industry led to an enormous increase of emission of fluoride ions into the biosphere. This made it more and more important to understand the biological activities, metabolism, degradation, and possible environmental hazards of such substances. This comprehensive and critical review focuses on the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment. To give a better overview, various connected topics are also discussed: reasons and trends of the advance of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of organic and inorganic fluorine compounds in the environment (including the biosphere), sources of fluoride intake, and finally biomarkers of fluoride exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.